Investigating the Possibility of Intervertebral Disc Regeneration Induced by Granulocyte Colony Stimulating Factor-Stimulated Stem Cells in Rats
Joint Authors
Tzaan, Wen-Ching
Chen, Hsien-Chih
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-11-21
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Intervertebral disc (IVD) degeneration is a multifactorial process that is influenced by contributions from genetic predisposition, the aging phenomenon, lifestyle conditions, biomechanical loading and activities, and other health factors (such as diabetes).
Attempts to decelerate disc degeneration using various techniques have been reported.
However, to date, there has been no proven technique effective for broad clinical application.
Granulocyte colony-stimulating factor (GCSF) is a growth factor cytokine that has been shown to enhance the availability of circulating hematopoietic stem cells to the brain and heart as well as their capacity for mobilization of mesenchymal bone marrow stem cells.
GCSF also exerts significant increases in circulating neutrophils as well as potent anti-inflammatory effects.
In our study, we hypothesize that GCSF can induce bone marrow stem cells differentiation and mobilization to regenerate the degenerated IVD.
We found that GCSF had no contribution in disc regeneration or maintenance; however, there were cell proliferation within end plates.
The effects of GCSF treatment on end plates might deserve further investigation.
American Psychological Association (APA)
Tzaan, Wen-Ching& Chen, Hsien-Chih. 2010. Investigating the Possibility of Intervertebral Disc Regeneration Induced by Granulocyte Colony Stimulating Factor-Stimulated Stem Cells in Rats. Advances in Orthopedics،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-484163
Modern Language Association (MLA)
Tzaan, Wen-Ching& Chen, Hsien-Chih. Investigating the Possibility of Intervertebral Disc Regeneration Induced by Granulocyte Colony Stimulating Factor-Stimulated Stem Cells in Rats. Advances in Orthopedics No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-484163
American Medical Association (AMA)
Tzaan, Wen-Ching& Chen, Hsien-Chih. Investigating the Possibility of Intervertebral Disc Regeneration Induced by Granulocyte Colony Stimulating Factor-Stimulated Stem Cells in Rats. Advances in Orthopedics. 2010. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-484163
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484163