Potentiometric Determination of Ketotifen Fumarate in Pharmaceutical Preparations and Urine Using Carbon Paste and PVC Membrane Selective Electrodes
المؤلفون المشاركون
Hwehy, Mohammad M. A.
Frag, Eman Y. Z.
Mohamed, Gehad G.
Khalil, Mohamed M.
المصدر
International Journal of Analytical Chemistry
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-10-13
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
This study compares between unmodified carbon paste (CPE; the paste has no ion pair) and polyvinyl chloride (PVC) membrane selective electrodes that were used in potentiometric determination of ketotifen fumarate (KTF), where sodium tetraphenylborate (NaTPB) was used as titrant.
The performance characteristics of these sensors were evaluated according to IUPAC recommendations which reveal a fast, stable, and linear response for KTF over the concentration range of 10-7 to 10-2 mol L-1.
The electrodes show Nernstian slope value of 52.51±0.20 and 51.51±0.25 mV decade-1 for CPE and PVC membrane electrodes at 30∘C, respectively.
The potential is nearly stable over the pH range 3.0–6.0 and 2.0–7.0 for CPE and PVC membrane electrodes, respectively.
Selectivity coefficient values towards different inorganic cations, sugars, and amino acids reflect high selectivity of the prepared electrodes.
The electrodes responses at different temperatures were also studied, and long operational lifetime of 12 and 5 weeks for CPE and PVC membrane electrodes, respectively, were found.
These are used for determination of ketotifen fumarate using potentiometric titration, calibration, and standard addition methods in pure samples, its pharmaceutical preparations (Zaditen tablets), and biological fluid (urine).
The direct potentiometric determination of KTF using the proposed sensors gave recoveries % of 98.97±0.53 and 98.62±0.74 with RSD 1.42 and 0.63% for CPE and PVC membrane selective electrodes, respectively.
Validation of the method shows suitability of the proposed sensors for use in quality control assessment of KTF.
The obtained results were in a good agreement with those obtained using the reported spectrophotometric method.Erratum of “Potentiometric Determination of Ketotifen Fumarate in Pharmaceutical Preparations and Urine Using Carbon Paste and PVC Membrane Selective Electrodes”dx.doi.org/10.1155/2012/154907
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Frag, Eman Y. Z.& Mohamed, Gehad G.& Khalil, Mohamed M.& Hwehy, Mohammad M. A.. 2011. Potentiometric Determination of Ketotifen Fumarate in Pharmaceutical Preparations and Urine Using Carbon Paste and PVC Membrane Selective Electrodes. International Journal of Analytical Chemistry،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-484421
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Frag, Eman Y. Z.…[et al.]. Potentiometric Determination of Ketotifen Fumarate in Pharmaceutical Preparations and Urine Using Carbon Paste and PVC Membrane Selective Electrodes. International Journal of Analytical Chemistry No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-484421
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Frag, Eman Y. Z.& Mohamed, Gehad G.& Khalil, Mohamed M.& Hwehy, Mohammad M. A.. Potentiometric Determination of Ketotifen Fumarate in Pharmaceutical Preparations and Urine Using Carbon Paste and PVC Membrane Selective Electrodes. International Journal of Analytical Chemistry. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-484421
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-484421
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر