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Potentiometric Determination of Ketotifen Fumarate in Pharmaceutical Preparations and Urine Using Carbon Paste and PVC Membrane Selective Electrodes
Joint Authors
Hwehy, Mohammad M. A.
Frag, Eman Y. Z.
Mohamed, Gehad G.
Khalil, Mohamed M.
Source
International Journal of Analytical Chemistry
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
This study compares between unmodified carbon paste (CPE; the paste has no ion pair) and polyvinyl chloride (PVC) membrane selective electrodes that were used in potentiometric determination of ketotifen fumarate (KTF), where sodium tetraphenylborate (NaTPB) was used as titrant.
The performance characteristics of these sensors were evaluated according to IUPAC recommendations which reveal a fast, stable, and linear response for KTF over the concentration range of 10-7 to 10-2 mol L-1.
The electrodes show Nernstian slope value of 52.51±0.20 and 51.51±0.25 mV decade-1 for CPE and PVC membrane electrodes at 30∘C, respectively.
The potential is nearly stable over the pH range 3.0–6.0 and 2.0–7.0 for CPE and PVC membrane electrodes, respectively.
Selectivity coefficient values towards different inorganic cations, sugars, and amino acids reflect high selectivity of the prepared electrodes.
The electrodes responses at different temperatures were also studied, and long operational lifetime of 12 and 5 weeks for CPE and PVC membrane electrodes, respectively, were found.
These are used for determination of ketotifen fumarate using potentiometric titration, calibration, and standard addition methods in pure samples, its pharmaceutical preparations (Zaditen tablets), and biological fluid (urine).
The direct potentiometric determination of KTF using the proposed sensors gave recoveries % of 98.97±0.53 and 98.62±0.74 with RSD 1.42 and 0.63% for CPE and PVC membrane selective electrodes, respectively.
Validation of the method shows suitability of the proposed sensors for use in quality control assessment of KTF.
The obtained results were in a good agreement with those obtained using the reported spectrophotometric method.Erratum of “Potentiometric Determination of Ketotifen Fumarate in Pharmaceutical Preparations and Urine Using Carbon Paste and PVC Membrane Selective Electrodes”dx.doi.org/10.1155/2012/154907
American Psychological Association (APA)
Frag, Eman Y. Z.& Mohamed, Gehad G.& Khalil, Mohamed M.& Hwehy, Mohammad M. A.. 2011. Potentiometric Determination of Ketotifen Fumarate in Pharmaceutical Preparations and Urine Using Carbon Paste and PVC Membrane Selective Electrodes. International Journal of Analytical Chemistry،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-484421
Modern Language Association (MLA)
Frag, Eman Y. Z.…[et al.]. Potentiometric Determination of Ketotifen Fumarate in Pharmaceutical Preparations and Urine Using Carbon Paste and PVC Membrane Selective Electrodes. International Journal of Analytical Chemistry No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-484421
American Medical Association (AMA)
Frag, Eman Y. Z.& Mohamed, Gehad G.& Khalil, Mohamed M.& Hwehy, Mohammad M. A.. Potentiometric Determination of Ketotifen Fumarate in Pharmaceutical Preparations and Urine Using Carbon Paste and PVC Membrane Selective Electrodes. International Journal of Analytical Chemistry. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-484421
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484421