Iron Inhibits Respiratory Burst of Peritoneal Phagocytes In Vitro

الملخص EN

Objective.

This study examines the effects of iron ions Fe3+ on the respiratory burst of phagocytes isolated from peritoneal effluents of continuous ambulatory peritoneal dialysis (CAPD) patients, as an in vitro model of iron overload in end-stage renal disease (ESRD).

Material and Methods.

Respiratory burst of peritoneal phagocytes was measured by chemiluminescence method.

Results.

At the highest used concentration of iron ions Fe3+ (100 μM), free radicals production by peritoneal phagocytes was reduced by 90% compared to control.

Conclusions.

Iron overload may increase the risk of infectious complications in ESRD patients.