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Risk and Determinants of Dementia in Patients with Mild Cognitive Impairment and Brain Subcortical Vascular Changes : A Study of Clinical, Neuroimaging, and Biological Markers—The VMCI-Tuscany Study: Rationale, Design, and Methodology
المؤلفون المشاركون
Ciolli, Laura
Cosottini, Mirco
Mascalchi, Mario
Dotti, Maria Teresa
Chiti, Alberto
Diciotti, Stefano
Pantoni, Leonardo
Inzitari, Domenico
Poggesi, Anna
Del Bene, Alessandra
Ginestroni, Andrea
Cesari, Francesca
Giusti, Betti
Salvadori, Emilia
Federico, Antonio
Valenti, Raffaella
Abbate, Rosanna
Pracucci, Giovanni
Orlandi, Giovanni
Murri, Luigi
De Stefano, Nicola
Nannucci, Serena
Pescini, Francesca
Gori, Anna Maria
المصدر
International Journal of Alzheimer's Disease
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-04-08
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Dementia is one of the most disabling conditions.
Alzheimer’s disease and vascular dementia (VaD) are the most frequent causes.
Subcortical VaD is consequent to deep-brain small vessel disease (SVD) and is the most frequent form of VaD.
Its pathological hallmarks are ischemic white matter changes and lacunar infarcts.
Degenerative and vascular changes often coexist, but mechanisms of interaction are incompletely understood.
The term mild cognitive impairment defines a transitional state between normal ageing and dementia.
Pre-dementia stages of VaD are also acknowledged (vascular mild cognitive impairment, VMCI).
Progression relates mostly to the subcortical VaD type, but determinants of such transition are unknown.
Variability of phenotypic expression is not fully explained by severity grade of lesions, as depicted by conventional MRI that is not sensitive to microstructural and metabolic alterations.
Advanced neuroimaging techniques seem able to achieve this.
Beside hypoperfusion, blood-brain-barrier dysfunction has been also demonstrated in subcortical VaD.
The aim of the Vascular Mild Cognitive Impairment Tuscany Study is to expand knowledge about determinants of transition from mild cognitive impairment to dementia in patients with cerebral SVD.
This paper summarizes the main aims and methodological aspects of this multicenter, ongoing, observational study enrolling patients affected by VMCI with SVD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Poggesi, Anna& Salvadori, Emilia& Pantoni, Leonardo& Pracucci, Giovanni& Cesari, Francesca& Chiti, Alberto…[et al.]. 2012. Risk and Determinants of Dementia in Patients with Mild Cognitive Impairment and Brain Subcortical Vascular Changes : A Study of Clinical, Neuroimaging, and Biological Markers—The VMCI-Tuscany Study: Rationale, Design, and Methodology. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-484700
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Poggesi, Anna…[et al.]. Risk and Determinants of Dementia in Patients with Mild Cognitive Impairment and Brain Subcortical Vascular Changes : A Study of Clinical, Neuroimaging, and Biological Markers—The VMCI-Tuscany Study: Rationale, Design, and Methodology. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-484700
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Poggesi, Anna& Salvadori, Emilia& Pantoni, Leonardo& Pracucci, Giovanni& Cesari, Francesca& Chiti, Alberto…[et al.]. Risk and Determinants of Dementia in Patients with Mild Cognitive Impairment and Brain Subcortical Vascular Changes : A Study of Clinical, Neuroimaging, and Biological Markers—The VMCI-Tuscany Study: Rationale, Design, and Methodology. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-484700
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-484700
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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