Risk and Determinants of Dementia in Patients with Mild Cognitive Impairment and Brain Subcortical Vascular Changes : A Study of Clinical, Neuroimaging, and Biological Markers—The VMCI-Tuscany Study: Rationale, Design, and Methodology
Joint Authors
Ciolli, Laura
Cosottini, Mirco
Mascalchi, Mario
Dotti, Maria Teresa
Chiti, Alberto
Diciotti, Stefano
Pantoni, Leonardo
Inzitari, Domenico
Poggesi, Anna
Del Bene, Alessandra
Ginestroni, Andrea
Cesari, Francesca
Giusti, Betti
Salvadori, Emilia
Federico, Antonio
Valenti, Raffaella
Abbate, Rosanna
Pracucci, Giovanni
Orlandi, Giovanni
Murri, Luigi
De Stefano, Nicola
Nannucci, Serena
Pescini, Francesca
Gori, Anna Maria
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Dementia is one of the most disabling conditions.
Alzheimer’s disease and vascular dementia (VaD) are the most frequent causes.
Subcortical VaD is consequent to deep-brain small vessel disease (SVD) and is the most frequent form of VaD.
Its pathological hallmarks are ischemic white matter changes and lacunar infarcts.
Degenerative and vascular changes often coexist, but mechanisms of interaction are incompletely understood.
The term mild cognitive impairment defines a transitional state between normal ageing and dementia.
Pre-dementia stages of VaD are also acknowledged (vascular mild cognitive impairment, VMCI).
Progression relates mostly to the subcortical VaD type, but determinants of such transition are unknown.
Variability of phenotypic expression is not fully explained by severity grade of lesions, as depicted by conventional MRI that is not sensitive to microstructural and metabolic alterations.
Advanced neuroimaging techniques seem able to achieve this.
Beside hypoperfusion, blood-brain-barrier dysfunction has been also demonstrated in subcortical VaD.
The aim of the Vascular Mild Cognitive Impairment Tuscany Study is to expand knowledge about determinants of transition from mild cognitive impairment to dementia in patients with cerebral SVD.
This paper summarizes the main aims and methodological aspects of this multicenter, ongoing, observational study enrolling patients affected by VMCI with SVD.
American Psychological Association (APA)
Poggesi, Anna& Salvadori, Emilia& Pantoni, Leonardo& Pracucci, Giovanni& Cesari, Francesca& Chiti, Alberto…[et al.]. 2012. Risk and Determinants of Dementia in Patients with Mild Cognitive Impairment and Brain Subcortical Vascular Changes : A Study of Clinical, Neuroimaging, and Biological Markers—The VMCI-Tuscany Study: Rationale, Design, and Methodology. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-484700
Modern Language Association (MLA)
Poggesi, Anna…[et al.]. Risk and Determinants of Dementia in Patients with Mild Cognitive Impairment and Brain Subcortical Vascular Changes : A Study of Clinical, Neuroimaging, and Biological Markers—The VMCI-Tuscany Study: Rationale, Design, and Methodology. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-484700
American Medical Association (AMA)
Poggesi, Anna& Salvadori, Emilia& Pantoni, Leonardo& Pracucci, Giovanni& Cesari, Francesca& Chiti, Alberto…[et al.]. Risk and Determinants of Dementia in Patients with Mild Cognitive Impairment and Brain Subcortical Vascular Changes : A Study of Clinical, Neuroimaging, and Biological Markers—The VMCI-Tuscany Study: Rationale, Design, and Methodology. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-484700
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484700