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Protective Mechanisms of S. lycopersicum Aqueous Fraction (Nucleosides and Flavonoids) on Platelet Activation and Thrombus Formation : In Vitro, Ex Vivo and In Vivo Studies
المؤلفون المشاركون
Fuentes, Eduardo
Valenzuela, Claudio
Palomo, Iván
Astudillo, Luis
Pereira, Jaime
Alarcón, Marcelo
Pérez, Pablo
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-16
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
The purpose of this research was to investigate mechanisms of antiplatelet action of bioactive principle from S.
lycopersicum.
Aqueous fraction had a high content of nucleosides (adenosine, guanosine, and adenosine 5′-monophosphate) by HPLC analysis.
Also aqueous fraction presented flavonoids content.
Aqueous fraction inhibited platelet activation by 15 ± 6% (P<0.05).
Fully spread of human platelets on collagen in the presence of aqueous fraction was inhibited from 15 ± 1 to 9 ± 1 μm2 (P<0.001).
After incubation of whole blood with aqueous fraction, the platelet coverage was inhibited by 55 ± 12% (P<0.001).
Platelet ATP secretion and aggregation were significantly inhibited by the aqueous fraction.
At the same concentrations that aqueous fraction inhibits platelet aggregation, levels of sCD40L significantly decreased and the intraplatelet cAMP levels increased.
In addition, SQ22536, an adenylate cyclase inhibitor, attenuated the effect of aqueous fraction toward ADP-induced platelet aggregation and intraplatelet level of cAMP.
Platelet aggregation ex vivo (human study) and thrombosis formation in vivo (murine model) were inhibited by aqueous fraction.
Finally, aqueous fraction may be used as a functional ingredient adding antiplatelet activities (nucleosides and flavonoids) to processed foods.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fuentes, Eduardo& Pereira, Jaime& Alarcón, Marcelo& Valenzuela, Claudio& Pérez, Pablo& Astudillo, Luis…[et al.]. 2013. Protective Mechanisms of S. lycopersicum Aqueous Fraction (Nucleosides and Flavonoids) on Platelet Activation and Thrombus Formation : In Vitro, Ex Vivo and In Vivo Studies. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-484878
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fuentes, Eduardo…[et al.]. Protective Mechanisms of S. lycopersicum Aqueous Fraction (Nucleosides and Flavonoids) on Platelet Activation and Thrombus Formation : In Vitro, Ex Vivo and In Vivo Studies. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-484878
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fuentes, Eduardo& Pereira, Jaime& Alarcón, Marcelo& Valenzuela, Claudio& Pérez, Pablo& Astudillo, Luis…[et al.]. Protective Mechanisms of S. lycopersicum Aqueous Fraction (Nucleosides and Flavonoids) on Platelet Activation and Thrombus Formation : In Vitro, Ex Vivo and In Vivo Studies. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-484878
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-484878
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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