Peroxisome Proliferator-Activated Receptor Alpha Target Genes

المؤلفون المشاركون

Müller, Michael M.
Knoch, Bianca
Kersten, Sander
Rakhshandehroo, Maryam

المصدر

PPAR Research

العدد

المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-20، 20ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2010-09-26

دولة النشر

مصر

عدد الصفحات

20

التخصصات الرئيسية

العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء

الملخص EN

The peroxisome proliferator-activated receptor alpha (PPARα) is a ligand-activated transcription factor involved in the regulation of a variety of processes, ranging from inflammation and immunity to nutrient metabolism and energy homeostasis.

PPARα serves as a molecular target for hypolipidemic fibrates drugs which bind the receptor with high affinity.

Furthermore, PPARα binds and is activated by numerous fatty acids and fatty acid-derived compounds.

PPARα governs biological processes by altering the expression of a large number of target genes.

Accordingly, the specific role of PPARα is directly related to the biological function of its target genes.

Here, we present an overview of the involvement of PPARα in lipid metabolism and other pathways through a detailed analysis of the different known or putative PPARα target genes.

The emphasis is on gene regulation by PPARα in liver although many of the results likely apply to other organs and tissues as well.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Rakhshandehroo, Maryam& Knoch, Bianca& Müller, Michael M.& Kersten, Sander. 2010. Peroxisome Proliferator-Activated Receptor Alpha Target Genes. PPAR Research،Vol. 2010, no. 2010, pp.1-20.
https://search.emarefa.net/detail/BIM-485025

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Rakhshandehroo, Maryam…[et al.]. Peroxisome Proliferator-Activated Receptor Alpha Target Genes. PPAR Research No. 2010 (2010), pp.1-20.
https://search.emarefa.net/detail/BIM-485025

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Rakhshandehroo, Maryam& Knoch, Bianca& Müller, Michael M.& Kersten, Sander. Peroxisome Proliferator-Activated Receptor Alpha Target Genes. PPAR Research. 2010. Vol. 2010, no. 2010, pp.1-20.
https://search.emarefa.net/detail/BIM-485025

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-485025