Peroxisome Proliferator-Activated Receptor Alpha Target Genes
Joint Authors
Müller, Michael M.
Knoch, Bianca
Kersten, Sander
Rakhshandehroo, Maryam
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-26
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The peroxisome proliferator-activated receptor alpha (PPARα) is a ligand-activated transcription factor involved in the regulation of a variety of processes, ranging from inflammation and immunity to nutrient metabolism and energy homeostasis.
PPARα serves as a molecular target for hypolipidemic fibrates drugs which bind the receptor with high affinity.
Furthermore, PPARα binds and is activated by numerous fatty acids and fatty acid-derived compounds.
PPARα governs biological processes by altering the expression of a large number of target genes.
Accordingly, the specific role of PPARα is directly related to the biological function of its target genes.
Here, we present an overview of the involvement of PPARα in lipid metabolism and other pathways through a detailed analysis of the different known or putative PPARα target genes.
The emphasis is on gene regulation by PPARα in liver although many of the results likely apply to other organs and tissues as well.
American Psychological Association (APA)
Rakhshandehroo, Maryam& Knoch, Bianca& Müller, Michael M.& Kersten, Sander. 2010. Peroxisome Proliferator-Activated Receptor Alpha Target Genes. PPAR Research،Vol. 2010, no. 2010, pp.1-20.
https://search.emarefa.net/detail/BIM-485025
Modern Language Association (MLA)
Rakhshandehroo, Maryam…[et al.]. Peroxisome Proliferator-Activated Receptor Alpha Target Genes. PPAR Research No. 2010 (2010), pp.1-20.
https://search.emarefa.net/detail/BIM-485025
American Medical Association (AMA)
Rakhshandehroo, Maryam& Knoch, Bianca& Müller, Michael M.& Kersten, Sander. Peroxisome Proliferator-Activated Receptor Alpha Target Genes. PPAR Research. 2010. Vol. 2010, no. 2010, pp.1-20.
https://search.emarefa.net/detail/BIM-485025
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485025