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Lamotrigine Augmentation of Serotonin Reuptake Inhibitors in Severe and Long-Term Treatment-Resistant Obsessive-Compulsive Disorder
المؤلفون المشاركون
Arrojo-Romero, Manuel
de Leon, Jose
Tajes Alonso, María
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-14
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
The treatment recommendations in obsessive-compulsive disorder (OCD) after lack of response to selective serotonin reuptake inhibitors (SSRIs) include augmentation with other drugs, particularly clomipramine, a more potent serotonin reuptake inhibitor (SRI), or antipsychotics.
We present two cases of response to lamotrigine augmentation in treatment-refractory OCD; each received multiple SRI trials over a >10-year period.
The first patient had eleven years of treatment with multiple combinations including clomipramine and SSRIs.
She had a >50% decrease of Y-BOCS (from 29 to 14) by augmenting paroxetine (60 mg/day) with lamotrigine (100 mg/day).
The second patient had 22 years of treatment with multiple combinations, including combinations of SSRIs with clomipramine and risperidone.
She had an almost 50% decrease of Y-BOCS (from 30 to 16) and disappearance of tics by augmenting clomipramine (225 mg/d) with lamotrigine (200 mg/day).
These two patients were characterized by lack of response to multiple treatments, making a placebo response to lamotrigine augmentation unlikely.
Prospective randomized trials in treatment-resistant OCD patients who do not respond to combinations of SSRIs with clomipramine and/or antipsychotics are needed, including augmentation with lamotrigine.
Until these trials are available, our cases suggest that clinicians may consider lamotrigine augmentation in such treatment-resistant OCD patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Arrojo-Romero, Manuel& Tajes Alonso, María& de Leon, Jose. 2013. Lamotrigine Augmentation of Serotonin Reuptake Inhibitors in Severe and Long-Term Treatment-Resistant Obsessive-Compulsive Disorder. Case Reports in Psychiatry،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-485052
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Arrojo-Romero, Manuel…[et al.]. Lamotrigine Augmentation of Serotonin Reuptake Inhibitors in Severe and Long-Term Treatment-Resistant Obsessive-Compulsive Disorder. Case Reports in Psychiatry No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-485052
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Arrojo-Romero, Manuel& Tajes Alonso, María& de Leon, Jose. Lamotrigine Augmentation of Serotonin Reuptake Inhibitors in Severe and Long-Term Treatment-Resistant Obsessive-Compulsive Disorder. Case Reports in Psychiatry. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-485052
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-485052
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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