Lamotrigine Augmentation of Serotonin Reuptake Inhibitors in Severe and Long-Term Treatment-Resistant Obsessive-Compulsive Disorder
Joint Authors
Arrojo-Romero, Manuel
de Leon, Jose
Tajes Alonso, María
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-14
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
The treatment recommendations in obsessive-compulsive disorder (OCD) after lack of response to selective serotonin reuptake inhibitors (SSRIs) include augmentation with other drugs, particularly clomipramine, a more potent serotonin reuptake inhibitor (SRI), or antipsychotics.
We present two cases of response to lamotrigine augmentation in treatment-refractory OCD; each received multiple SRI trials over a >10-year period.
The first patient had eleven years of treatment with multiple combinations including clomipramine and SSRIs.
She had a >50% decrease of Y-BOCS (from 29 to 14) by augmenting paroxetine (60 mg/day) with lamotrigine (100 mg/day).
The second patient had 22 years of treatment with multiple combinations, including combinations of SSRIs with clomipramine and risperidone.
She had an almost 50% decrease of Y-BOCS (from 30 to 16) and disappearance of tics by augmenting clomipramine (225 mg/d) with lamotrigine (200 mg/day).
These two patients were characterized by lack of response to multiple treatments, making a placebo response to lamotrigine augmentation unlikely.
Prospective randomized trials in treatment-resistant OCD patients who do not respond to combinations of SSRIs with clomipramine and/or antipsychotics are needed, including augmentation with lamotrigine.
Until these trials are available, our cases suggest that clinicians may consider lamotrigine augmentation in such treatment-resistant OCD patients.
American Psychological Association (APA)
Arrojo-Romero, Manuel& Tajes Alonso, María& de Leon, Jose. 2013. Lamotrigine Augmentation of Serotonin Reuptake Inhibitors in Severe and Long-Term Treatment-Resistant Obsessive-Compulsive Disorder. Case Reports in Psychiatry،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-485052
Modern Language Association (MLA)
Arrojo-Romero, Manuel…[et al.]. Lamotrigine Augmentation of Serotonin Reuptake Inhibitors in Severe and Long-Term Treatment-Resistant Obsessive-Compulsive Disorder. Case Reports in Psychiatry No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-485052
American Medical Association (AMA)
Arrojo-Romero, Manuel& Tajes Alonso, María& de Leon, Jose. Lamotrigine Augmentation of Serotonin Reuptake Inhibitors in Severe and Long-Term Treatment-Resistant Obsessive-Compulsive Disorder. Case Reports in Psychiatry. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-485052
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485052