Both IL-1β and TNF-α Regulate NGAL Expression in Polymorphonuclear Granulocytes of Chronic Hemodialysis Patients
المؤلفون المشاركون
Arena, Adriana
Iannello, Daniela
Buemi, Michele
Gazzara, Domenica
Lacquaniti, Antonio
Calapai, Maria
Bolignano, Davide
Bisignano, Carlo
Stassi, Giovanna
المصدر
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-03-03
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
NGAL is involved in modulation of the inflammatory response and is found in the sera of uremic patients.
We investigated whether hemodiafiltration (HDF) could influence the ability of polymorphonuclear granulocytes (PMGs) to release NGAL.
The involvement of interleukin- (IL-)1β and tumor necrosis factor- (TNF-)α on NGAL release was evaluated.
Methods.
We studied end-stage renal disease (ESRD) patients at the start of dialysis (Pre-HDF) and at the end of treatment (Post-HDF) and 18 healthy subjects (HSs).
Peripheral venous blood was taken from HDF patients at the start of dialysis and at the end of treatment.
Results.
PMGs obtained from ESRD patients were hyporesponsive to LPS treatment, with respect to PMG from HS.
IL-1β and TNF-α produced by PMG from post-HDF patients were higher than those obtained by PMG from pre-HDF.
Neutralization of IL-1β, but not of TNF-α, determined a clear-cut production of NGAL in PMG from healthy donors.
On the contrary, specific induction of NGAL in PMG from uremic patients was dependent on the presence in supernatants of IL-1β and TNF-α.
Conclusion.
Our data demonstrate that in PMG from healthy subjects, NGAL production was supported solely by IL-1β, whereas in PMG from HDF patients, NGAL production was supported by IL-1β, TNF-α.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Arena, Adriana& Stassi, Giovanna& Iannello, Daniela& Gazzara, Domenica& Calapai, Maria& Bisignano, Carlo…[et al.]. 2011. Both IL-1β and TNF-α Regulate NGAL Expression in Polymorphonuclear Granulocytes of Chronic Hemodialysis Patients. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-485183
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Arena, Adriana…[et al.]. Both IL-1β and TNF-α Regulate NGAL Expression in Polymorphonuclear Granulocytes of Chronic Hemodialysis Patients. Mediators of Inflammation No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-485183
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Arena, Adriana& Stassi, Giovanna& Iannello, Daniela& Gazzara, Domenica& Calapai, Maria& Bisignano, Carlo…[et al.]. Both IL-1β and TNF-α Regulate NGAL Expression in Polymorphonuclear Granulocytes of Chronic Hemodialysis Patients. Mediators of Inflammation. 2011. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-485183
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-485183
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر