Primitive Sca-1 Positive Bone Marrow HSC in Mouse Model of Aplastic Anemia : A Comparative Study through Flowcytometric Analysis and Scanning Electron Microscopy
المؤلفون المشاركون
Das, Prosun
Chaklader, Malay
Dutta, Ranjan Kumar
Pereira, Jacintha Archana
Law, Sujata
Chaudhuri, Samaresh
Chatterjee, Sumanta
Basak, Pratima
Das, Madhurima
المصدر
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-10-28
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الملخص EN
Self-renewing Hematopoietic Stem Cells (HSCs) are responsible for reconstitution of all blood cell lineages.
Sca-1 is the “stem cell antigen” marker used to identify the primitive murine HSC population, the expression of which decreases upon differentiation to other mature cell types.
Sca-1+ HSCs maintain the bone marrow stem cell pool throughout the life.
Aplastic anemia is a disease considered to involve primary stem cell deficiency and is characterized by severe pancytopenia and a decline in healthy blood cell generation system.
Studies conducted in our laboratory revealed that the primitive Sca-1+ BM-HSCs (bone marrow hematopoietic stem cell) are significantly affected in experimental Aplastic animals pretreated with chemotherapeutic drugs (Busulfan and Cyclophosphamide) and there is increased Caspase-3 activity with consecutive high Annexin-V positivity leading to premature apoptosis in the bone marrow hematopoietic stem cell population in Aplastic condition.
The Sca-1bright, that is, “more primitive” BM-HSC population was more affected than the “less primitive” BM-HSC Sca-1dim population.
The decreased cell population and the receptor expression were directly associated with an empty and deranged marrow microenvironment, which is evident from scanning electron microscopy (SEM).
The above experimental evidences hint toward the manipulation of receptor expression for the benefit of cytotherapy by primitive stem cell population in Aplastic anemia cases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chatterjee, Sumanta& Basak, Pratima& Das, Prosun& Das, Madhurima& Pereira, Jacintha Archana& Dutta, Ranjan Kumar…[et al.]. 2009. Primitive Sca-1 Positive Bone Marrow HSC in Mouse Model of Aplastic Anemia : A Comparative Study through Flowcytometric Analysis and Scanning Electron Microscopy. Stem Cells International،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-485238
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chatterjee, Sumanta…[et al.]. Primitive Sca-1 Positive Bone Marrow HSC in Mouse Model of Aplastic Anemia : A Comparative Study through Flowcytometric Analysis and Scanning Electron Microscopy. Stem Cells International No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-485238
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chatterjee, Sumanta& Basak, Pratima& Das, Prosun& Das, Madhurima& Pereira, Jacintha Archana& Dutta, Ranjan Kumar…[et al.]. Primitive Sca-1 Positive Bone Marrow HSC in Mouse Model of Aplastic Anemia : A Comparative Study through Flowcytometric Analysis and Scanning Electron Microscopy. Stem Cells International. 2009. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-485238
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-485238
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر