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Effects of Splenectomy on Spontaneously Chronic Pancreatitis in alyaly Mice
المؤلفون المشاركون
Naito, Munekazu
Wang, Heng-Xiao
Qu, Ning
Hirai, Shuichi
Itoh, Masahiro
Terayama, Hayato
Yi, Shuang-Qin
Li, Jun
Yi, Nozomi
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-03-30
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background and Aim.
Mice with alymphoplasia (aly/aly) mutation characterized by a lack of lymph nodes, Peyer's patches, and well-defined lymphoid follicles in the spleen were found.
In this study, we used splenectomized aly/aly mice to elucidate the effects of secondary lymphoid organs in the development of aly/aly autoimmune pancreatitis.
Methods.
Forty-eight 10-week-old aly/aly mice were divided into two groups for splenectomy and sham operation.
Histological and immunohistochemical analyses of the pancreas were performed at the ages of 20, 30, and 40 weeks old after operation, respectively.
Results.
Our results showed that mononuclear cell infiltration was restricted to the interlobular connective tissues at the age of 20 weeks, and not increase obviously at the age of 30 and 40 weeks in splenectomized aly/aly mice.
Furthermore, an apparent decrease in the expressions of CD4+ T, CD8+ T, and B cells was detected in the pancreatic tissues compared with sham aly/aly mice, however, no significant difference in macrophage expression between mice with and without a splenectomy.
Conclusions.
Inflammation infiltration and development of the pancreatitis in aly/aly mice were suppressed effectively after splenectomy, which was, at least partly, correlated to inhibition of the infiltration of T and B cells in pancreatic tissues but not to macrophages.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Heng-Xiao& Yi, Shuang-Qin& Li, Jun& Terayama, Hayato& Naito, Munekazu& Hirai, Shuichi…[et al.]. 2010. Effects of Splenectomy on Spontaneously Chronic Pancreatitis in alyaly Mice. Clinical and Developmental Immunology،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-485279
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Heng-Xiao…[et al.]. Effects of Splenectomy on Spontaneously Chronic Pancreatitis in alyaly Mice. Clinical and Developmental Immunology No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-485279
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Heng-Xiao& Yi, Shuang-Qin& Li, Jun& Terayama, Hayato& Naito, Munekazu& Hirai, Shuichi…[et al.]. Effects of Splenectomy on Spontaneously Chronic Pancreatitis in alyaly Mice. Clinical and Developmental Immunology. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-485279
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-485279
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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