Effects of Splenectomy on Spontaneously Chronic Pancreatitis in alyaly Mice
Joint Authors
Naito, Munekazu
Wang, Heng-Xiao
Qu, Ning
Hirai, Shuichi
Itoh, Masahiro
Terayama, Hayato
Yi, Shuang-Qin
Li, Jun
Yi, Nozomi
Source
Clinical and Developmental Immunology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background and Aim.
Mice with alymphoplasia (aly/aly) mutation characterized by a lack of lymph nodes, Peyer's patches, and well-defined lymphoid follicles in the spleen were found.
In this study, we used splenectomized aly/aly mice to elucidate the effects of secondary lymphoid organs in the development of aly/aly autoimmune pancreatitis.
Methods.
Forty-eight 10-week-old aly/aly mice were divided into two groups for splenectomy and sham operation.
Histological and immunohistochemical analyses of the pancreas were performed at the ages of 20, 30, and 40 weeks old after operation, respectively.
Results.
Our results showed that mononuclear cell infiltration was restricted to the interlobular connective tissues at the age of 20 weeks, and not increase obviously at the age of 30 and 40 weeks in splenectomized aly/aly mice.
Furthermore, an apparent decrease in the expressions of CD4+ T, CD8+ T, and B cells was detected in the pancreatic tissues compared with sham aly/aly mice, however, no significant difference in macrophage expression between mice with and without a splenectomy.
Conclusions.
Inflammation infiltration and development of the pancreatitis in aly/aly mice were suppressed effectively after splenectomy, which was, at least partly, correlated to inhibition of the infiltration of T and B cells in pancreatic tissues but not to macrophages.
American Psychological Association (APA)
Wang, Heng-Xiao& Yi, Shuang-Qin& Li, Jun& Terayama, Hayato& Naito, Munekazu& Hirai, Shuichi…[et al.]. 2010. Effects of Splenectomy on Spontaneously Chronic Pancreatitis in alyaly Mice. Clinical and Developmental Immunology،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-485279
Modern Language Association (MLA)
Wang, Heng-Xiao…[et al.]. Effects of Splenectomy on Spontaneously Chronic Pancreatitis in alyaly Mice. Clinical and Developmental Immunology No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-485279
American Medical Association (AMA)
Wang, Heng-Xiao& Yi, Shuang-Qin& Li, Jun& Terayama, Hayato& Naito, Munekazu& Hirai, Shuichi…[et al.]. Effects of Splenectomy on Spontaneously Chronic Pancreatitis in alyaly Mice. Clinical and Developmental Immunology. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-485279
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485279