Human Elimination of Phthalate Compounds : Blood, Urine, and Sweat (BUS) Study
المؤلفون المشاركون
Lobo, Rebecca A.
Birkholz, Detlef
Genuis, Stephen J.
Beesoon, Sanjay
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-10-31
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
Background.
Individual members of the phthalate family of chemical compounds are components of innumerable everyday consumer products, resulting in a high exposure scenario for some individuals and population groups.
Multiple epidemiological studies have demonstrated statistically significant exposure-disease relationships involving phthalates and toxicological studies have shown estrogenic effects in vitro.
Data is lacking in the medical literature, however, on effective means to facilitate phthalate excretion.
Methods.
Blood, urine, and sweat were collected from 20 individuals (10 healthy participants and 10 participants with assorted health problems) and analyzed for parent phthalate compounds as well as phthalate metabolites using high performance liquid chromatography-tandem mass spectrometry.
Results.
Some parent phthalates as well as their metabolites were excreted into sweat.
All patients had MEHP (mono(2-ethylhexyl) phthalate) in their blood, sweat, and urine samples, suggesting widespread phthalate exposure.
In several individuals, DEHP (di (2-ethylhexl) phthalate) was found in sweat but not in serum, suggesting the possibility of phthalate retention and bioaccumulation.
On average, MEHP concentration in sweat was more than twice as high as urine levels.
Conclusions.
Induced perspiration may be useful to facilitate elimination of some potentially toxic phthalate compounds including DEHP and MEHP.
Sweat analysis may be helpful in establishing the existence of accrued DEHP in the human body.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Genuis, Stephen J.& Beesoon, Sanjay& Lobo, Rebecca A.& Birkholz, Detlef. 2012. Human Elimination of Phthalate Compounds : Blood, Urine, and Sweat (BUS) Study. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-485296
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Genuis, Stephen J.…[et al.]. Human Elimination of Phthalate Compounds : Blood, Urine, and Sweat (BUS) Study. The Scientific World Journal No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-485296
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Genuis, Stephen J.& Beesoon, Sanjay& Lobo, Rebecca A.& Birkholz, Detlef. Human Elimination of Phthalate Compounds : Blood, Urine, and Sweat (BUS) Study. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-485296
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-485296
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر