Human Elimination of Phthalate Compounds : Blood, Urine, and Sweat (BUS) Study
Joint Authors
Lobo, Rebecca A.
Birkholz, Detlef
Genuis, Stephen J.
Beesoon, Sanjay
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Background.
Individual members of the phthalate family of chemical compounds are components of innumerable everyday consumer products, resulting in a high exposure scenario for some individuals and population groups.
Multiple epidemiological studies have demonstrated statistically significant exposure-disease relationships involving phthalates and toxicological studies have shown estrogenic effects in vitro.
Data is lacking in the medical literature, however, on effective means to facilitate phthalate excretion.
Methods.
Blood, urine, and sweat were collected from 20 individuals (10 healthy participants and 10 participants with assorted health problems) and analyzed for parent phthalate compounds as well as phthalate metabolites using high performance liquid chromatography-tandem mass spectrometry.
Results.
Some parent phthalates as well as their metabolites were excreted into sweat.
All patients had MEHP (mono(2-ethylhexyl) phthalate) in their blood, sweat, and urine samples, suggesting widespread phthalate exposure.
In several individuals, DEHP (di (2-ethylhexl) phthalate) was found in sweat but not in serum, suggesting the possibility of phthalate retention and bioaccumulation.
On average, MEHP concentration in sweat was more than twice as high as urine levels.
Conclusions.
Induced perspiration may be useful to facilitate elimination of some potentially toxic phthalate compounds including DEHP and MEHP.
Sweat analysis may be helpful in establishing the existence of accrued DEHP in the human body.
American Psychological Association (APA)
Genuis, Stephen J.& Beesoon, Sanjay& Lobo, Rebecca A.& Birkholz, Detlef. 2012. Human Elimination of Phthalate Compounds : Blood, Urine, and Sweat (BUS) Study. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-485296
Modern Language Association (MLA)
Genuis, Stephen J.…[et al.]. Human Elimination of Phthalate Compounds : Blood, Urine, and Sweat (BUS) Study. The Scientific World Journal No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-485296
American Medical Association (AMA)
Genuis, Stephen J.& Beesoon, Sanjay& Lobo, Rebecca A.& Birkholz, Detlef. Human Elimination of Phthalate Compounds : Blood, Urine, and Sweat (BUS) Study. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-485296
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485296