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The Role of the Immune System in Obesity and Insulin Resistance
المؤلفون المشاركون
Patel, Payal S.
Balasubramanyam, Ashok
Buras, Eric D.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-03-21
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The innate immune system provides organisms with rapid and well-coordinated protection from foreign pathogens.
However, under certain conditions of metabolic dysfunction, components of the innate immune system may be activated in the absence of external pathogens, leading to pathologic consequences.
Indeed, there appears to be an intimate relationship between metabolic diseases and immune dysfunction; for example, macrophages are prime players in the initiation of a chronic inflammatory state in obesity which leads to insulin resistance.
In response to increases in free fatty acid release from obese adipose depots, M1-polarized macrophages infiltrate adipose tissues.
These M1 macrophages trigger inflammatory signaling and stress responses within cells that signal through JNK or IKKβ pathways, leading to insulin resistance.
If overnutrition persists, mechanisms that counteract inflammation (such as M2 macrophages and PPAR signaling) are suppressed, and the inflammation becomes chronic.
Although macrophages are a principal constituent of obese adipose tissue inflammation, other components of the immune system such as lymphocytes and mast cells also contribute to the inflammatory cascade.
Thus it is not merely an increased mass of adipose tissue that directly leads to attenuation of insulin action, but rather adipose tissue inflammation activated by the immune system in obese individuals that leads to insulin resistance.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Patel, Payal S.& Buras, Eric D.& Balasubramanyam, Ashok. 2013. The Role of the Immune System in Obesity and Insulin Resistance. Journal of Obesity،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-485390
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Patel, Payal S.…[et al.]. The Role of the Immune System in Obesity and Insulin Resistance. Journal of Obesity No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-485390
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Patel, Payal S.& Buras, Eric D.& Balasubramanyam, Ashok. The Role of the Immune System in Obesity and Insulin Resistance. Journal of Obesity. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-485390
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-485390
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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