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The Immunosuppressive Activity of Heat Shock Protein 70
المؤلفون المشاركون
Stocki, Pawel
Dickinson, Anne M.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-17
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Heat shock protein 70 (HSP70) has previously been described as a potent antitumour vaccine.
The mechanism relied on the ability of tumour derived HSP70 to associate with antigenic peptides, which, when cross presented, elicited a T cell mediated antitumour response.
Subsequently, HSP70 was incorrectly described as a potent adjuvant of innate immunity, and although mistakes in the experimental approaches were exposed and associated with endotoxin contamination in the recombinant HSP70 specimen, questions still remain regarding this matter.
Here we review only publications that have cautiously addressed the endotoxin contamination problem in HSP70 in order to reveal the real immunological function of the protein.
Accordingly, “endotoxin free” HSP70 stimulates macrophages and delivers antigenic peptides to APCs, which effectively prime T cells mediating an antitumour reaction.
Conversely, HSP70 has potent anti-inflammatory functions as follows: regulating T cell responses, reducing stimulatory capacity of DCs, and inducing development of immunosuppressive regulatory T cells.
These activities were further associated with the immune evasive mechanism of tumours and implicated in the modulation of immune reactivity in autoimmune diseases and transplant-related clinical conditions.
Consequently, the role of HSP70 in immune regulation is newly emerging and contrary to what was previously anticipated.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Stocki, Pawel& Dickinson, Anne M.. 2012. The Immunosuppressive Activity of Heat Shock Protein 70. Autoimmune Diseases،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-485465
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Stocki, Pawel& Dickinson, Anne M.. The Immunosuppressive Activity of Heat Shock Protein 70. Autoimmune Diseases No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-485465
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Stocki, Pawel& Dickinson, Anne M.. The Immunosuppressive Activity of Heat Shock Protein 70. Autoimmune Diseases. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-485465
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-485465
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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