The Immunosuppressive Activity of Heat Shock Protein 70
Joint Authors
Stocki, Pawel
Dickinson, Anne M.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Heat shock protein 70 (HSP70) has previously been described as a potent antitumour vaccine.
The mechanism relied on the ability of tumour derived HSP70 to associate with antigenic peptides, which, when cross presented, elicited a T cell mediated antitumour response.
Subsequently, HSP70 was incorrectly described as a potent adjuvant of innate immunity, and although mistakes in the experimental approaches were exposed and associated with endotoxin contamination in the recombinant HSP70 specimen, questions still remain regarding this matter.
Here we review only publications that have cautiously addressed the endotoxin contamination problem in HSP70 in order to reveal the real immunological function of the protein.
Accordingly, “endotoxin free” HSP70 stimulates macrophages and delivers antigenic peptides to APCs, which effectively prime T cells mediating an antitumour reaction.
Conversely, HSP70 has potent anti-inflammatory functions as follows: regulating T cell responses, reducing stimulatory capacity of DCs, and inducing development of immunosuppressive regulatory T cells.
These activities were further associated with the immune evasive mechanism of tumours and implicated in the modulation of immune reactivity in autoimmune diseases and transplant-related clinical conditions.
Consequently, the role of HSP70 in immune regulation is newly emerging and contrary to what was previously anticipated.
American Psychological Association (APA)
Stocki, Pawel& Dickinson, Anne M.. 2012. The Immunosuppressive Activity of Heat Shock Protein 70. Autoimmune Diseases،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-485465
Modern Language Association (MLA)
Stocki, Pawel& Dickinson, Anne M.. The Immunosuppressive Activity of Heat Shock Protein 70. Autoimmune Diseases No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-485465
American Medical Association (AMA)
Stocki, Pawel& Dickinson, Anne M.. The Immunosuppressive Activity of Heat Shock Protein 70. Autoimmune Diseases. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-485465
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485465