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Synergistic Antibacterial Effect between Silibinin and Antibiotics in Oral Bacteria
المؤلفون المشاركون
Lee, Young-Soo
Cha, Jeong-Dan
Jang, Kyeung-Ae
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-09-15
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Silibinin is a composition of the silymarin group as a hepatoprotective agent, and it exhibits various biological activities, including antibacterial activity.
In this study, the antibacterial activities of silibinin were investigated in combination with two antimicrobial agents against oral bacteria.
Silibinin was determined with MIC and MBC values ranging from 0.1 to 3.2 and 0.2 to 6.4 μg/mL, ampicillin from 0.125 to 64 and 0.5 to 64 μg/mL, gentamicin from 2 to 256 and 4 to 512 μg/mL, respectively.
The ranges of MIC50 and MIC90 were 0.025–0.8 μg/mL and 0.1–3.2 μg/mL, respectively.
The antibacterial activities of silibinin against oral bacteria were assessed using the checkerboard and time-kill methods to evaluate the synergistic effects of treatment with ampicillin or gentamicin.
The results were evaluated showing that the combination effects of silibinin with antibiotics were synergistic (FIC index <0.5) against all tested oral bacteria.
Furthermore, a time-kill study showed that the growth of the tested bacteria was completely attenuated after 2–6 h of treatment with the MBC of silibinin, regardless of whether it was administered alone or with ampicillin or gentamicin.
These results suggest that silibinin combined with other antibiotics may be microbiologically beneficial and not antagonistic.\
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Young-Soo& Jang, Kyeung-Ae& Cha, Jeong-Dan. 2011. Synergistic Antibacterial Effect between Silibinin and Antibiotics in Oral Bacteria. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-485556
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Young-Soo…[et al.]. Synergistic Antibacterial Effect between Silibinin and Antibiotics in Oral Bacteria. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-485556
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Young-Soo& Jang, Kyeung-Ae& Cha, Jeong-Dan. Synergistic Antibacterial Effect between Silibinin and Antibiotics in Oral Bacteria. Journal of Biomedicine and Biotechnology. 2011. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-485556
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-485556
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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