Synergistic Antibacterial Effect between Silibinin and Antibiotics in Oral Bacteria
Joint Authors
Lee, Young-Soo
Cha, Jeong-Dan
Jang, Kyeung-Ae
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Silibinin is a composition of the silymarin group as a hepatoprotective agent, and it exhibits various biological activities, including antibacterial activity.
In this study, the antibacterial activities of silibinin were investigated in combination with two antimicrobial agents against oral bacteria.
Silibinin was determined with MIC and MBC values ranging from 0.1 to 3.2 and 0.2 to 6.4 μg/mL, ampicillin from 0.125 to 64 and 0.5 to 64 μg/mL, gentamicin from 2 to 256 and 4 to 512 μg/mL, respectively.
The ranges of MIC50 and MIC90 were 0.025–0.8 μg/mL and 0.1–3.2 μg/mL, respectively.
The antibacterial activities of silibinin against oral bacteria were assessed using the checkerboard and time-kill methods to evaluate the synergistic effects of treatment with ampicillin or gentamicin.
The results were evaluated showing that the combination effects of silibinin with antibiotics were synergistic (FIC index <0.5) against all tested oral bacteria.
Furthermore, a time-kill study showed that the growth of the tested bacteria was completely attenuated after 2–6 h of treatment with the MBC of silibinin, regardless of whether it was administered alone or with ampicillin or gentamicin.
These results suggest that silibinin combined with other antibiotics may be microbiologically beneficial and not antagonistic.\
American Psychological Association (APA)
Lee, Young-Soo& Jang, Kyeung-Ae& Cha, Jeong-Dan. 2011. Synergistic Antibacterial Effect between Silibinin and Antibiotics in Oral Bacteria. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-485556
Modern Language Association (MLA)
Lee, Young-Soo…[et al.]. Synergistic Antibacterial Effect between Silibinin and Antibiotics in Oral Bacteria. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-485556
American Medical Association (AMA)
Lee, Young-Soo& Jang, Kyeung-Ae& Cha, Jeong-Dan. Synergistic Antibacterial Effect between Silibinin and Antibiotics in Oral Bacteria. Journal of Biomedicine and Biotechnology. 2011. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-485556
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485556