Biodistribution and SPECT Imaging Study of 99mTc Labeling NGR Peptide in Nude Mice Bearing Human HepG2 Hepatoma
المؤلفون المشاركون
Wang, Jing
Ma, Wenhui
Kang, Fei
Yang, Weidong
Ma, Xiaowei
Wang, Zhe
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-18
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
A peptide containing Asn-Gly-Arg(NGR) sequence was synthesized and directly labeled with Tc.
Its radiochemical characteristics, biodistribution, and SPECT imaging were evaluated in nude mice bearing human HepG2 hepatoma.
Nude mice bearing HepG2 were randomly divided into 5 groups with 5 mice in each group and injected with ~7.4 MBq Tc-NGR.
The SPECT images were acquired in 1, 4, 8, and 12 h postinjection via caudal vein.
The metabolism of tracers was determined in major organs at different time points, which demonstrated rapid, significant tumor uptake and slow tumor washout.
The control group mice were blocked by coinjecting unlabelled NGR (20 mg/kg).
Tumor uptake was (2.52±0.83%) ID/g at 1 h, with the highest uptake of (3.26±0.63%) ID/g at 8 h.
In comparison, the uptake of the blocked control group was (1.65±0.61%) ID/g at 1 h after injection.
The SPECT static images and the tumor/muscle (T/NT) value were obtained.
The highest T/NT value was 7.58±1.92 at 8 h.
The xenografted tumor became visible at 1 h and the clearest image of the tumor was observed at 8 h.
In conclusion, Tc-NGR can be efficiently prepared and it exhibited good properties for the potential SPECT imaging agent of tumor.Erratum to “Biodistribution and SPECT Imaging Study of 99mTc Labeling NGR Peptide in Nude Mice Bearing Human HepG2 Hepatoma”dx.doi.org/10.1155/2014/798474
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ma, Wenhui& Wang, Zhe& Yang, Weidong& Ma, Xiaowei& Kang, Fei& Wang, Jing. 2014. Biodistribution and SPECT Imaging Study of 99mTc Labeling NGR Peptide in Nude Mice Bearing Human HepG2 Hepatoma. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-485558
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ma, Wenhui…[et al.]. Biodistribution and SPECT Imaging Study of 99mTc Labeling NGR Peptide in Nude Mice Bearing Human HepG2 Hepatoma. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-485558
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ma, Wenhui& Wang, Zhe& Yang, Weidong& Ma, Xiaowei& Kang, Fei& Wang, Jing. Biodistribution and SPECT Imaging Study of 99mTc Labeling NGR Peptide in Nude Mice Bearing Human HepG2 Hepatoma. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-485558
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-485558
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر