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Biodistribution and SPECT Imaging Study of 99mTc Labeling NGR Peptide in Nude Mice Bearing Human HepG2 Hepatoma
Joint Authors
Wang, Jing
Ma, Wenhui
Kang, Fei
Yang, Weidong
Ma, Xiaowei
Wang, Zhe
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
A peptide containing Asn-Gly-Arg(NGR) sequence was synthesized and directly labeled with Tc.
Its radiochemical characteristics, biodistribution, and SPECT imaging were evaluated in nude mice bearing human HepG2 hepatoma.
Nude mice bearing HepG2 were randomly divided into 5 groups with 5 mice in each group and injected with ~7.4 MBq Tc-NGR.
The SPECT images were acquired in 1, 4, 8, and 12 h postinjection via caudal vein.
The metabolism of tracers was determined in major organs at different time points, which demonstrated rapid, significant tumor uptake and slow tumor washout.
The control group mice were blocked by coinjecting unlabelled NGR (20 mg/kg).
Tumor uptake was (2.52±0.83%) ID/g at 1 h, with the highest uptake of (3.26±0.63%) ID/g at 8 h.
In comparison, the uptake of the blocked control group was (1.65±0.61%) ID/g at 1 h after injection.
The SPECT static images and the tumor/muscle (T/NT) value were obtained.
The highest T/NT value was 7.58±1.92 at 8 h.
The xenografted tumor became visible at 1 h and the clearest image of the tumor was observed at 8 h.
In conclusion, Tc-NGR can be efficiently prepared and it exhibited good properties for the potential SPECT imaging agent of tumor.Erratum to “Biodistribution and SPECT Imaging Study of 99mTc Labeling NGR Peptide in Nude Mice Bearing Human HepG2 Hepatoma”dx.doi.org/10.1155/2014/798474
American Psychological Association (APA)
Ma, Wenhui& Wang, Zhe& Yang, Weidong& Ma, Xiaowei& Kang, Fei& Wang, Jing. 2014. Biodistribution and SPECT Imaging Study of 99mTc Labeling NGR Peptide in Nude Mice Bearing Human HepG2 Hepatoma. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-485558
Modern Language Association (MLA)
Ma, Wenhui…[et al.]. Biodistribution and SPECT Imaging Study of 99mTc Labeling NGR Peptide in Nude Mice Bearing Human HepG2 Hepatoma. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-485558
American Medical Association (AMA)
Ma, Wenhui& Wang, Zhe& Yang, Weidong& Ma, Xiaowei& Kang, Fei& Wang, Jing. Biodistribution and SPECT Imaging Study of 99mTc Labeling NGR Peptide in Nude Mice Bearing Human HepG2 Hepatoma. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-485558
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485558