Regulation of DDAH1 as a Potential Therapeutic Target for Treating Cardiovascular Diseases

المؤلفون المشاركون

Fassett, John
Chen, Yingjie
Liu, Xiaoyu
Wei, Yidong

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-06-26

دولة النشر

مصر

عدد الصفحات

6

التخصصات الرئيسية

الطب البشري

الملخص EN

Asymmetric dimethylarginine (ADMA) is an endogenous nitric oxide synthase inhibitor that blocks nitric oxide production, while congestive heart failure is associated with increased plasma and tissue ADMA content.

Increased plasma ADMA is a strong and independent predictor of all-cause mortality in the community and the strongest predictor of mortality in patients after myocardial infarction.

Recent studies demonstrated that dimethylarginine dimethylaminohydrolase-1 (DDAH1) is the critical enzyme for ADMA degradation and thereby plays an important role in maintaining cardiovascular nitric oxide bioavailability.

Interestingly, activation of the farnesoid X receptor (FXR) through the bile acid ursodeoxycholic acid (UDCA) or synthetic FXR agonists, such as GW4064, can increase DDAH1 expression.

Thus, modulating DDAH1 activity through FXR receptor agonists such as UDCA could be a therapeutic target for treating reduced nitric oxide bioavailability in congestive heart failure and other cardiovascular diseases.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Liu, Xiaoyu& Fassett, John& Wei, Yidong& Chen, Yingjie. 2013. Regulation of DDAH1 as a Potential Therapeutic Target for Treating Cardiovascular Diseases. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-485659

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Liu, Xiaoyu…[et al.]. Regulation of DDAH1 as a Potential Therapeutic Target for Treating Cardiovascular Diseases. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-485659

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Liu, Xiaoyu& Fassett, John& Wei, Yidong& Chen, Yingjie. Regulation of DDAH1 as a Potential Therapeutic Target for Treating Cardiovascular Diseases. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-485659

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-485659