Regulation of DDAH1 as a Potential Therapeutic Target for Treating Cardiovascular Diseases
Joint Authors
Fassett, John
Chen, Yingjie
Liu, Xiaoyu
Wei, Yidong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Asymmetric dimethylarginine (ADMA) is an endogenous nitric oxide synthase inhibitor that blocks nitric oxide production, while congestive heart failure is associated with increased plasma and tissue ADMA content.
Increased plasma ADMA is a strong and independent predictor of all-cause mortality in the community and the strongest predictor of mortality in patients after myocardial infarction.
Recent studies demonstrated that dimethylarginine dimethylaminohydrolase-1 (DDAH1) is the critical enzyme for ADMA degradation and thereby plays an important role in maintaining cardiovascular nitric oxide bioavailability.
Interestingly, activation of the farnesoid X receptor (FXR) through the bile acid ursodeoxycholic acid (UDCA) or synthetic FXR agonists, such as GW4064, can increase DDAH1 expression.
Thus, modulating DDAH1 activity through FXR receptor agonists such as UDCA could be a therapeutic target for treating reduced nitric oxide bioavailability in congestive heart failure and other cardiovascular diseases.
American Psychological Association (APA)
Liu, Xiaoyu& Fassett, John& Wei, Yidong& Chen, Yingjie. 2013. Regulation of DDAH1 as a Potential Therapeutic Target for Treating Cardiovascular Diseases. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-485659
Modern Language Association (MLA)
Liu, Xiaoyu…[et al.]. Regulation of DDAH1 as a Potential Therapeutic Target for Treating Cardiovascular Diseases. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-485659
American Medical Association (AMA)
Liu, Xiaoyu& Fassett, John& Wei, Yidong& Chen, Yingjie. Regulation of DDAH1 as a Potential Therapeutic Target for Treating Cardiovascular Diseases. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-485659
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485659