Sensitive and Selective Spectrophotometric Determination of Gabapentin in Capsules Using Two Nitrophenols as Chromogenic Agents
المؤلفون المشاركون
Abdulrahman, Sameer. A. M.
Basavaiah, Kanakapura
المصدر
International Journal of Analytical Chemistry
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-06-22
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Two simple and selective spectrophotometric methods have been proposed for the determination of gabapentin (GBP) in pure form and in capsules.
Both methods are based on the proton transfer from the Lewis acid such as 2,4,6-trinitrophenol (picric acid; PA) or 2,4-dinitrophenol (2,4-DNP) to the primary amino group of GBP which works as Lewis base and formation of yellow ion-pair complexes.
The ion-pair complexes formed show absorption maximum at 415 and 420 nm for PA and 2,4-DNP, respectively.
Under the optimized experimental conditions, Beer's law is obeyed over the concentration ranges of 1.25–15.0 and 2.0–18.0 μg mL−1 GBP for PA and 2,4-DNP methods, respectively.
The molar absorptivity, Sandell's sensitivity, detection and, quantification limits for both methods are also reported.
The proposed methods were applied successfully to the determination of GBP in pure form and commercial capsules.
Statistical comparison of the results was performed using Student's t-test and F-ratio at 95% confidence level, and there was no significant difference between the reference and proposed methods with regard to accuracy and precision.
Further, the validity of the proposed methods was confirmed by recovery studies via standard addition technique.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abdulrahman, Sameer. A. M.& Basavaiah, Kanakapura. 2011. Sensitive and Selective Spectrophotometric Determination of Gabapentin in Capsules Using Two Nitrophenols as Chromogenic Agents. International Journal of Analytical Chemistry،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-485668
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abdulrahman, Sameer. A. M.& Basavaiah, Kanakapura. Sensitive and Selective Spectrophotometric Determination of Gabapentin in Capsules Using Two Nitrophenols as Chromogenic Agents. International Journal of Analytical Chemistry No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-485668
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abdulrahman, Sameer. A. M.& Basavaiah, Kanakapura. Sensitive and Selective Spectrophotometric Determination of Gabapentin in Capsules Using Two Nitrophenols as Chromogenic Agents. International Journal of Analytical Chemistry. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-485668
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-485668
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر