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Sensitive and Selective Spectrophotometric Determination of Gabapentin in Capsules Using Two Nitrophenols as Chromogenic Agents
Joint Authors
Abdulrahman, Sameer. A. M.
Basavaiah, Kanakapura
Source
International Journal of Analytical Chemistry
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Two simple and selective spectrophotometric methods have been proposed for the determination of gabapentin (GBP) in pure form and in capsules.
Both methods are based on the proton transfer from the Lewis acid such as 2,4,6-trinitrophenol (picric acid; PA) or 2,4-dinitrophenol (2,4-DNP) to the primary amino group of GBP which works as Lewis base and formation of yellow ion-pair complexes.
The ion-pair complexes formed show absorption maximum at 415 and 420 nm for PA and 2,4-DNP, respectively.
Under the optimized experimental conditions, Beer's law is obeyed over the concentration ranges of 1.25–15.0 and 2.0–18.0 μg mL−1 GBP for PA and 2,4-DNP methods, respectively.
The molar absorptivity, Sandell's sensitivity, detection and, quantification limits for both methods are also reported.
The proposed methods were applied successfully to the determination of GBP in pure form and commercial capsules.
Statistical comparison of the results was performed using Student's t-test and F-ratio at 95% confidence level, and there was no significant difference between the reference and proposed methods with regard to accuracy and precision.
Further, the validity of the proposed methods was confirmed by recovery studies via standard addition technique.
American Psychological Association (APA)
Abdulrahman, Sameer. A. M.& Basavaiah, Kanakapura. 2011. Sensitive and Selective Spectrophotometric Determination of Gabapentin in Capsules Using Two Nitrophenols as Chromogenic Agents. International Journal of Analytical Chemistry،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-485668
Modern Language Association (MLA)
Abdulrahman, Sameer. A. M.& Basavaiah, Kanakapura. Sensitive and Selective Spectrophotometric Determination of Gabapentin in Capsules Using Two Nitrophenols as Chromogenic Agents. International Journal of Analytical Chemistry No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-485668
American Medical Association (AMA)
Abdulrahman, Sameer. A. M.& Basavaiah, Kanakapura. Sensitive and Selective Spectrophotometric Determination of Gabapentin in Capsules Using Two Nitrophenols as Chromogenic Agents. International Journal of Analytical Chemistry. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-485668
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485668