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iSS-PseDNC : Identifying Splicing Sites Using Pseudo Dinucleotide Composition
المؤلفون المشاركون
Lin, Hao
Chou, Kuo-Chen
Chen, Wei
Feng, Peng-Mian
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-21
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
In eukaryotic genes, exons are generally interrupted by introns.
Accurately removing introns and joining exons together are essential processes in eukaryotic gene expression.
With the avalanche of genome sequences generated in the postgenomic age, it is highly desired to develop automated methods for rapid and effective detection of splice sites that play important roles in gene structure annotation and even in RNA splicing.
Although a series of computational methods were proposed for splice site identification, most of them neglected the intrinsic local structural properties.
In the present study, a predictor called “iSS-PseDNC” was developed for identifying splice sites.
In the new predictor, the sequences were formulated by a novel feature-vector called “pseudo dinucleotide composition” (PseDNC) into which six DNA local structural properties were incorporated.
It was observed by the rigorous cross-validation tests on two benchmark datasets that the overall success rates achieved by iSS-PseDNC in identifying splice donor site and splice acceptor site were 85.45% and 87.73%, respectively.
It is anticipated that iSS-PseDNC may become a useful tool for identifying splice sites and that the six DNA local structural properties described in this paper may provide novel insights for in-depth investigations into the mechanism of RNA splicing.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Wei& Feng, Peng-Mian& Lin, Hao& Chou, Kuo-Chen. 2014. iSS-PseDNC : Identifying Splicing Sites Using Pseudo Dinucleotide Composition. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-485936
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Wei…[et al.]. iSS-PseDNC : Identifying Splicing Sites Using Pseudo Dinucleotide Composition. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-485936
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Wei& Feng, Peng-Mian& Lin, Hao& Chou, Kuo-Chen. iSS-PseDNC : Identifying Splicing Sites Using Pseudo Dinucleotide Composition. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-485936
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-485936
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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