iSS-PseDNC : Identifying Splicing Sites Using Pseudo Dinucleotide Composition
Joint Authors
Lin, Hao
Chou, Kuo-Chen
Chen, Wei
Feng, Peng-Mian
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-21
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
In eukaryotic genes, exons are generally interrupted by introns.
Accurately removing introns and joining exons together are essential processes in eukaryotic gene expression.
With the avalanche of genome sequences generated in the postgenomic age, it is highly desired to develop automated methods for rapid and effective detection of splice sites that play important roles in gene structure annotation and even in RNA splicing.
Although a series of computational methods were proposed for splice site identification, most of them neglected the intrinsic local structural properties.
In the present study, a predictor called “iSS-PseDNC” was developed for identifying splice sites.
In the new predictor, the sequences were formulated by a novel feature-vector called “pseudo dinucleotide composition” (PseDNC) into which six DNA local structural properties were incorporated.
It was observed by the rigorous cross-validation tests on two benchmark datasets that the overall success rates achieved by iSS-PseDNC in identifying splice donor site and splice acceptor site were 85.45% and 87.73%, respectively.
It is anticipated that iSS-PseDNC may become a useful tool for identifying splice sites and that the six DNA local structural properties described in this paper may provide novel insights for in-depth investigations into the mechanism of RNA splicing.
American Psychological Association (APA)
Chen, Wei& Feng, Peng-Mian& Lin, Hao& Chou, Kuo-Chen. 2014. iSS-PseDNC : Identifying Splicing Sites Using Pseudo Dinucleotide Composition. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-485936
Modern Language Association (MLA)
Chen, Wei…[et al.]. iSS-PseDNC : Identifying Splicing Sites Using Pseudo Dinucleotide Composition. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-485936
American Medical Association (AMA)
Chen, Wei& Feng, Peng-Mian& Lin, Hao& Chou, Kuo-Chen. iSS-PseDNC : Identifying Splicing Sites Using Pseudo Dinucleotide Composition. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-485936
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485936