Gray Matter Pathology in MS : Neuroimaging and Clinical Correlations

المؤلف

Honce, Justin Morris

المصدر

Multiple Sclerosis International

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-16، 16ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-06-25

دولة النشر

مصر

عدد الصفحات

16

التخصصات الرئيسية

الطب البشري

الملخص EN

It is abundantly clear that there is extensive gray matter pathology occurring in multiple sclerosis.

While attention to gray matter pathology was initially limited to studies of autopsy specimens and biopsies, the development of new MRI techniques has allowed assessment of gray matter pathology in vivo.

Current MRI techniques allow the direct visualization of gray matter demyelinating lesions, the quantification of diffuse damage to normal appearing gray matter, and the direct measurement of gray matter atrophy.

Gray matter demyelination (both focal and diffuse) and gray matter atrophy are found in the very earliest stages of multiple sclerosis and are progressive over time.

Accumulation of gray matter damage has substantial impact on the lives of multiple sclerosis patients; a growing body of the literature demonstrates correlations between gray matter pathology and various measures of both clinical disability and cognitive impairment.

The effect of disease modifying therapies on the rate accumulation of gray matter pathology in MS has been investigated.

This review focuses on the neuroimaging of gray matter pathology in MS, the effect of the accumulation of gray matter pathology on clinical and cognitive disability, and the effect of disease-modifying agents on various measures of gray matter damage.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Honce, Justin Morris. 2013. Gray Matter Pathology in MS : Neuroimaging and Clinical Correlations. Multiple Sclerosis International،Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-486322

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Honce, Justin Morris. Gray Matter Pathology in MS : Neuroimaging and Clinical Correlations. Multiple Sclerosis International No. 2013 (2013), pp.1-16.
https://search.emarefa.net/detail/BIM-486322

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Honce, Justin Morris. Gray Matter Pathology in MS : Neuroimaging and Clinical Correlations. Multiple Sclerosis International. 2013. Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-486322

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-486322