Gray Matter Pathology in MS : Neuroimaging and Clinical Correlations
Author
Source
Multiple Sclerosis International
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-25
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
It is abundantly clear that there is extensive gray matter pathology occurring in multiple sclerosis.
While attention to gray matter pathology was initially limited to studies of autopsy specimens and biopsies, the development of new MRI techniques has allowed assessment of gray matter pathology in vivo.
Current MRI techniques allow the direct visualization of gray matter demyelinating lesions, the quantification of diffuse damage to normal appearing gray matter, and the direct measurement of gray matter atrophy.
Gray matter demyelination (both focal and diffuse) and gray matter atrophy are found in the very earliest stages of multiple sclerosis and are progressive over time.
Accumulation of gray matter damage has substantial impact on the lives of multiple sclerosis patients; a growing body of the literature demonstrates correlations between gray matter pathology and various measures of both clinical disability and cognitive impairment.
The effect of disease modifying therapies on the rate accumulation of gray matter pathology in MS has been investigated.
This review focuses on the neuroimaging of gray matter pathology in MS, the effect of the accumulation of gray matter pathology on clinical and cognitive disability, and the effect of disease-modifying agents on various measures of gray matter damage.
American Psychological Association (APA)
Honce, Justin Morris. 2013. Gray Matter Pathology in MS : Neuroimaging and Clinical Correlations. Multiple Sclerosis International،Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-486322
Modern Language Association (MLA)
Honce, Justin Morris. Gray Matter Pathology in MS : Neuroimaging and Clinical Correlations. Multiple Sclerosis International No. 2013 (2013), pp.1-16.
https://search.emarefa.net/detail/BIM-486322
American Medical Association (AMA)
Honce, Justin Morris. Gray Matter Pathology in MS : Neuroimaging and Clinical Correlations. Multiple Sclerosis International. 2013. Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-486322
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486322