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The Role of Glucocorticoid Receptors in Dexamethasone-Induced Apoptosis of Neuroprogenitor Cells in the Hippocampus of Rat Pups
المؤلفون المشاركون
Sze, Chun-I
Hsieh, Ting-Hui
Kuo, Yu Min
Lin, Yung-Chieh
Lin, Chyi-Her
Lin, Yuh-Jyh
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-01-14
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Dexamethasone (Dex) has been used to reduce inflammation in preterm infants with assistive ventilation and to prevent chronic lung diseases.
However, Dex treatment results in adverse effects on the brain.
Since the hippocampus contains a high density of glucocorticoid receptors (GCRs), we hypothesized that Dex affects neurogenesis in the hippocampus through inflammatory mediators.
Methods.
Albino Wistar rat pups first received a single dose of Dex (0.5 mg/kg) on postnatal day 1 (P1) and were sacrificed on P2, P3, P5, and P7.
One group of Dex-treated pups (Dex-treated D1D2) was given mifepristone (RU486, a GCR antagonist) on P1 and sacrificed on P2.
Hippocampi were isolated for western blot analysis, TUNEL, cleaved-caspase 3 staining for cell counts, and morphological assessment.
Control pups received normal saline (NS).
Results.
Dex reduced the developmental gain in body weight, but had no effect on brain weight.
In the Dex-treated D1D2 group, apoptotic cells increased in number based on TUNEL and cleaved-caspase 3 staining.
Most of the apoptotic cells expressed the neural progenitor cell marker nestin.
Dex-induced apoptosis in P1 pups was markedly reduced (60%) by pretreatment with RU486, indicating the involvement of GCRs.
Conclusion.
Early administration of Dex results in apoptosis of neural progenitor cells in the hippocampus and this is mediated through GCRs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sze, Chun-I& Lin, Yung-Chieh& Lin, Yuh-Jyh& Hsieh, Ting-Hui& Kuo, Yu Min& Lin, Chyi-Her. 2013. The Role of Glucocorticoid Receptors in Dexamethasone-Induced Apoptosis of Neuroprogenitor Cells in the Hippocampus of Rat Pups. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-486347
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sze, Chun-I…[et al.]. The Role of Glucocorticoid Receptors in Dexamethasone-Induced Apoptosis of Neuroprogenitor Cells in the Hippocampus of Rat Pups. Mediators of Inflammation No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-486347
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sze, Chun-I& Lin, Yung-Chieh& Lin, Yuh-Jyh& Hsieh, Ting-Hui& Kuo, Yu Min& Lin, Chyi-Her. The Role of Glucocorticoid Receptors in Dexamethasone-Induced Apoptosis of Neuroprogenitor Cells in the Hippocampus of Rat Pups. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-486347
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-486347
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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