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Lymphocytes Mitochondrial Physiology as Biomarker of Energy Metabolism during Fasted and Fed Conditions
المؤلفون المشاركون
Cortez, Erika
Carvalho, Laís
Stumbo, Ana Carolina
Sichieri, Rosely
Bernardo, Amélia F.
Neves, Fabiana A.
Moura, Anibal S.
Garcia-Souza, Érica
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-12
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
Mitochondria are central coordinators of energy metabolism, and changes of their physiology have long been associated with metabolic disorders.
Thus, observations of energy dynamics in different cell types are of utmost importance.
Therefore, tools with quick and easy handling are needed for consistent evaluations of such interventions.
In this paper, our main hypothesis is that during different nutritional situations lymphocytes mitochondrial physiology could be associated with the metabolism of other cell types, such as cardiomyocytes, and consequently be used as metabolic biomarker.
Blood lymphocytes and heart muscle fibers were obtained from both fed and 24 h-fasted mice, and mitochondrial analysis was assessed by high-resolution respirometry and western blotting.
Carbohydrate-linked oxidation and fatty acid oxidation were significantly higher after fasting.
Carnitine palmitoil transferase 1 and uncouple protein 2 contents were increased in the fasted group, while the glucose transporters 1 and 4 and the ratio phosphorylated AMP-activated protein kinase/AMPK did not change between groups.
In summary, under a nutritional status modification, mitochondria demonstrated earlier adaptive capacity than other metabolic sensors such as glucose transporters and AMPK, suggesting the accuracy of mitochondria physiology of lymphocytes as biomarker for metabolic changes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cortez, Erika& Neves, Fabiana A.& Bernardo, Amélia F.& Stumbo, Ana Carolina& Carvalho, Laís& Garcia-Souza, Érica…[et al.]. 2012. Lymphocytes Mitochondrial Physiology as Biomarker of Energy Metabolism during Fasted and Fed Conditions. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-486470
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cortez, Erika…[et al.]. Lymphocytes Mitochondrial Physiology as Biomarker of Energy Metabolism during Fasted and Fed Conditions. The Scientific World Journal No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-486470
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cortez, Erika& Neves, Fabiana A.& Bernardo, Amélia F.& Stumbo, Ana Carolina& Carvalho, Laís& Garcia-Souza, Érica…[et al.]. Lymphocytes Mitochondrial Physiology as Biomarker of Energy Metabolism during Fasted and Fed Conditions. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-486470
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-486470
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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