Systemic Revealing Pharmacological Signalling Pathway Networks in the Hippocampus of Ischaemia-Reperfusion Mice Treated with Baicalin
المؤلفون المشاركون
Wu, Hongli
Wang, Jie
Li, Bing
Chen, YinYing
Tian, Jinzhou
Wang, Zhong
Li, Jun
Li, Haixia
Yu, Yanan
Zhang, Yingying
Xiong, Xingjiang
He, Qiongyong
Wang, Jingtao
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-17
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
Baicalin (BA) exhibits ill understood neuroprotective, anti-inflammatory, and antioxidative effects in brain injury.
Objective.
To identify the differential network pathways associated with BA-related biological effects.
Methods.
MCAO-induced mice received BA 5 mg/Kg (BA group).
Controls received vehicle only.
Following ischaemia-reperfusion, ArrayTrack analysed the whole genome microarray of hippocampal genes, and MetaCore analysed differentially expressed genes.
Results.
Four reversing pathways were common to BA and controls, but only 6 were in the top 10 for BA.
Three of the top 5 signalling pathways in controls were not observed in BA.
BA treatment made absent 3 pathways of the top 5 signalling pathways from the top 5 in controls.
There were 2 reversing pathways between controls and BA that showed altered gene expression.
Controls had 6 networks associated with cerebral ischaemia.
After BA treatment, 9 networks were associated with cerebral ischaemia.
Enrichment analysis identified 10 significant biological processes in BA and controls.
Of the 10 most significant molecular functions, 7 were common to BA and controls, and only 3 occurred in BA.
BA and controls had 7 significant cellular components.
Conclusions.
This study showed that the clinical effectiveness of BA was based on the complementary effects of multiple pathways and networks.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Haixia& Zhang, Yingying& Yu, Yanan& Li, Bing& Chen, YinYing& Wu, Hongli…[et al.]. 2013. Systemic Revealing Pharmacological Signalling Pathway Networks in the Hippocampus of Ischaemia-Reperfusion Mice Treated with Baicalin. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-486585
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Haixia…[et al.]. Systemic Revealing Pharmacological Signalling Pathway Networks in the Hippocampus of Ischaemia-Reperfusion Mice Treated with Baicalin. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-486585
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Haixia& Zhang, Yingying& Yu, Yanan& Li, Bing& Chen, YinYing& Wu, Hongli…[et al.]. Systemic Revealing Pharmacological Signalling Pathway Networks in the Hippocampus of Ischaemia-Reperfusion Mice Treated with Baicalin. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-486585
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-486585
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر