Increased Serum Levels and Chondrocyte Expression of Nesfatin-1 in Patients with Osteoarthritis and Its Relation with BMI, hsCRP, and IL-18
المؤلفون المشاركون
Zhou, Xindie
Jiang, Lifeng
Xiong, Yan
Wu, Lidong
Bao, Jiapeng
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-23
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Adipokines have been proved to relate with osteoarthritis (OA).
As a recently discovered adipokine, nesfatin-1 relationship with OA has not been reported.
Aim.
To determine the levels of nesfatin-1 in serum and synovial fluid (SF) from patients with and without OA; to examine the correlation between nesfatin-1 levels and high sensitivity C-reactive protein (hsCRP), Type IIA Collagen N Propeptide (PIIANP), and IL-18 (interleukin-18) levels in serum or synovial fluid.
Methods.
Serum and SF were collected from knee OA patients and healthy persons, respectively.
Five articular tissues were obtained during TKR for immunohistochemistry (IHC).
Nesfatin-1 levels, hsCRP, PIIANP, and IL-18 in serum and SF were analyzed by enzyme-linked immunosorbent assay (ELISA).
Results.
Nesfatin-1 gene was expressed in OA-affected articular cartilage.
OA serum contained significantly higher levels of nesfatin-1, as compared to serum from healthy controls (P<0.05), and nesfatin-1 levels in OA serum exceeded those in paired SF samples (P<0.001).
Significant correlation was found between serum nesfatin-1 and hsCRP levels in OA patients (r=0.593, P=0.00005) and also synovial nesfatin-1 and IL-18 levels (r=0.560, P=0.0017).
Conclusion.
Nesfatin-1 is present in articular tissues and may contribute to the physiopathologic changes in OA.
Nesfatin-1, accompanied with hsCRP and IL-18, could be new molecular makers to speculate OA progression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jiang, Lifeng& Bao, Jiapeng& Zhou, Xindie& Xiong, Yan& Wu, Lidong. 2013. Increased Serum Levels and Chondrocyte Expression of Nesfatin-1 in Patients with Osteoarthritis and Its Relation with BMI, hsCRP, and IL-18. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-486634
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jiang, Lifeng…[et al.]. Increased Serum Levels and Chondrocyte Expression of Nesfatin-1 in Patients with Osteoarthritis and Its Relation with BMI, hsCRP, and IL-18. Mediators of Inflammation No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-486634
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jiang, Lifeng& Bao, Jiapeng& Zhou, Xindie& Xiong, Yan& Wu, Lidong. Increased Serum Levels and Chondrocyte Expression of Nesfatin-1 in Patients with Osteoarthritis and Its Relation with BMI, hsCRP, and IL-18. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-486634
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-486634
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر