Increased Serum Levels and Chondrocyte Expression of Nesfatin-1 in Patients with Osteoarthritis and Its Relation with BMI, hsCRP, and IL-18
Joint Authors
Zhou, Xindie
Jiang, Lifeng
Xiong, Yan
Wu, Lidong
Bao, Jiapeng
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Adipokines have been proved to relate with osteoarthritis (OA).
As a recently discovered adipokine, nesfatin-1 relationship with OA has not been reported.
Aim.
To determine the levels of nesfatin-1 in serum and synovial fluid (SF) from patients with and without OA; to examine the correlation between nesfatin-1 levels and high sensitivity C-reactive protein (hsCRP), Type IIA Collagen N Propeptide (PIIANP), and IL-18 (interleukin-18) levels in serum or synovial fluid.
Methods.
Serum and SF were collected from knee OA patients and healthy persons, respectively.
Five articular tissues were obtained during TKR for immunohistochemistry (IHC).
Nesfatin-1 levels, hsCRP, PIIANP, and IL-18 in serum and SF were analyzed by enzyme-linked immunosorbent assay (ELISA).
Results.
Nesfatin-1 gene was expressed in OA-affected articular cartilage.
OA serum contained significantly higher levels of nesfatin-1, as compared to serum from healthy controls (P<0.05), and nesfatin-1 levels in OA serum exceeded those in paired SF samples (P<0.001).
Significant correlation was found between serum nesfatin-1 and hsCRP levels in OA patients (r=0.593, P=0.00005) and also synovial nesfatin-1 and IL-18 levels (r=0.560, P=0.0017).
Conclusion.
Nesfatin-1 is present in articular tissues and may contribute to the physiopathologic changes in OA.
Nesfatin-1, accompanied with hsCRP and IL-18, could be new molecular makers to speculate OA progression.
American Psychological Association (APA)
Jiang, Lifeng& Bao, Jiapeng& Zhou, Xindie& Xiong, Yan& Wu, Lidong. 2013. Increased Serum Levels and Chondrocyte Expression of Nesfatin-1 in Patients with Osteoarthritis and Its Relation with BMI, hsCRP, and IL-18. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-486634
Modern Language Association (MLA)
Jiang, Lifeng…[et al.]. Increased Serum Levels and Chondrocyte Expression of Nesfatin-1 in Patients with Osteoarthritis and Its Relation with BMI, hsCRP, and IL-18. Mediators of Inflammation No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-486634
American Medical Association (AMA)
Jiang, Lifeng& Bao, Jiapeng& Zhou, Xindie& Xiong, Yan& Wu, Lidong. Increased Serum Levels and Chondrocyte Expression of Nesfatin-1 in Patients with Osteoarthritis and Its Relation with BMI, hsCRP, and IL-18. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-486634
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486634