Evaluation of Correlation of Cell Cycle Proteins and Ki-67 Interaction in Paranasal Sinus Inverted Papilloma Prognosis and Squamous Cell Carcinoma Transformation
المؤلفون المشاركون
Chen, Calvin Yu-Chian
Chen, Chuan-Mu
Huang, Hung-Jin
Tai, Chih-Jaan
Tsou, Yung-An
Wang, Tang-Chuan
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-12
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
The recurrent sinonasal inverted papilloma (IP) could be transformed to sinonasal squamous cell carcinoma.
We use protein expression patterns by immunohistochemical method to see whether the expression of p53, p16, p21, and p27 belongs to cell-cycle-regulators and PCNA (proliferating cell nuclear antigen) and Ki-67 the proliferation markers in sixty patients with sinonasal inverted papilloma, and 10 of them with squamous cell carcinoma transformation.
Significantly elevated levels of Ki-67, p27, and PCNA in IP with squamous cell carcinoma transformation of sinonasal tract compared with inverted papilloma were revealed.
No variation of p16, p21, PLUNC (palate, lung, and nasal epithelium clone protein) and p53 expression was correlated to sinonasal IP malignant transformation by multivariate survey.
However, we found elevated PLUNC expression in IPs with multiple recurrences.
Finally, we found that PCNA, p27 may interact with CDK1 which promote IP cell proliferation and correlate to sinonasal squamous cell carcinoma.
Ki-67 could work throughout the cell cycles to cause malignant transformation.
In conclusion, this is a first study showing the correlation of Ki-67, PCNA interacted with CDK1 might lead to malignant transformation.
Elevated PLUNC expression in the sinonasal IPs was related to multiple recurrences in human.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tsou, Yung-An& Huang, Hung-Jin& Wang, Tang-Chuan& Tai, Chih-Jaan& Chen, Chuan-Mu& Chen, Calvin Yu-Chian. 2014. Evaluation of Correlation of Cell Cycle Proteins and Ki-67 Interaction in Paranasal Sinus Inverted Papilloma Prognosis and Squamous Cell Carcinoma Transformation. BioMed Research International،Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-486904
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tsou, Yung-An…[et al.]. Evaluation of Correlation of Cell Cycle Proteins and Ki-67 Interaction in Paranasal Sinus Inverted Papilloma Prognosis and Squamous Cell Carcinoma Transformation. BioMed Research International No. 2014 (2014), pp.1-16.
https://search.emarefa.net/detail/BIM-486904
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tsou, Yung-An& Huang, Hung-Jin& Wang, Tang-Chuan& Tai, Chih-Jaan& Chen, Chuan-Mu& Chen, Calvin Yu-Chian. Evaluation of Correlation of Cell Cycle Proteins and Ki-67 Interaction in Paranasal Sinus Inverted Papilloma Prognosis and Squamous Cell Carcinoma Transformation. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-486904
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-486904
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر