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Evaluation of Correlation of Cell Cycle Proteins and Ki-67 Interaction in Paranasal Sinus Inverted Papilloma Prognosis and Squamous Cell Carcinoma Transformation
Joint Authors
Chen, Calvin Yu-Chian
Chen, Chuan-Mu
Huang, Hung-Jin
Tai, Chih-Jaan
Tsou, Yung-An
Wang, Tang-Chuan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-12
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The recurrent sinonasal inverted papilloma (IP) could be transformed to sinonasal squamous cell carcinoma.
We use protein expression patterns by immunohistochemical method to see whether the expression of p53, p16, p21, and p27 belongs to cell-cycle-regulators and PCNA (proliferating cell nuclear antigen) and Ki-67 the proliferation markers in sixty patients with sinonasal inverted papilloma, and 10 of them with squamous cell carcinoma transformation.
Significantly elevated levels of Ki-67, p27, and PCNA in IP with squamous cell carcinoma transformation of sinonasal tract compared with inverted papilloma were revealed.
No variation of p16, p21, PLUNC (palate, lung, and nasal epithelium clone protein) and p53 expression was correlated to sinonasal IP malignant transformation by multivariate survey.
However, we found elevated PLUNC expression in IPs with multiple recurrences.
Finally, we found that PCNA, p27 may interact with CDK1 which promote IP cell proliferation and correlate to sinonasal squamous cell carcinoma.
Ki-67 could work throughout the cell cycles to cause malignant transformation.
In conclusion, this is a first study showing the correlation of Ki-67, PCNA interacted with CDK1 might lead to malignant transformation.
Elevated PLUNC expression in the sinonasal IPs was related to multiple recurrences in human.
American Psychological Association (APA)
Tsou, Yung-An& Huang, Hung-Jin& Wang, Tang-Chuan& Tai, Chih-Jaan& Chen, Chuan-Mu& Chen, Calvin Yu-Chian. 2014. Evaluation of Correlation of Cell Cycle Proteins and Ki-67 Interaction in Paranasal Sinus Inverted Papilloma Prognosis and Squamous Cell Carcinoma Transformation. BioMed Research International،Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-486904
Modern Language Association (MLA)
Tsou, Yung-An…[et al.]. Evaluation of Correlation of Cell Cycle Proteins and Ki-67 Interaction in Paranasal Sinus Inverted Papilloma Prognosis and Squamous Cell Carcinoma Transformation. BioMed Research International No. 2014 (2014), pp.1-16.
https://search.emarefa.net/detail/BIM-486904
American Medical Association (AMA)
Tsou, Yung-An& Huang, Hung-Jin& Wang, Tang-Chuan& Tai, Chih-Jaan& Chen, Chuan-Mu& Chen, Calvin Yu-Chian. Evaluation of Correlation of Cell Cycle Proteins and Ki-67 Interaction in Paranasal Sinus Inverted Papilloma Prognosis and Squamous Cell Carcinoma Transformation. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-486904
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486904