The Inhibition of Folylpolyglutamate Synthetase (folC) in the Prevention of Drug Resistance in Mycobacterium tuberculosis by Traditional Chinese Medicine
المؤلفون المشاركون
Lee, Wen-Yuan
Chen, Kuen-Bao
Chen, Calvin Yu-Chian
Hung, Tzu-Chieh
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-19
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Tuberculosis (TB) is an infectious disease caused by many strains of mycobacteria, but commonly Mycobacterium tuberculosis.
As a possible method of reducing the drug resistance of M.
tuberculosis, this research investigates the inhibition of Folylpolyglutamate synthetase, a protein transcript from the resistance association gene folC.
After molecular docking to screen the traditional Chinese medicine (TCM) database, the candidate TCM compounds, with Folylpolyglutamate synthetase, were selected by molecular dynamics.
The 10,000 ps simulation in association with RMSD analysis and total energy and structural variation defined the protein-ligand interaction.
The selected TCM compounds Saussureamine C, methyl 3-O-feruloylquinate, and Labiatic acid have been found to inhibit the activity of bacteria and viruses and to regulate immunity.
We also suggest the possible pathway in protein for each ligand.
Compared with the control, similar interactions and structural variations indicate that these compounds might have an effect on Folylpolyglutamate synthetase.
Finally, we suggest Saussureamine C is the best candidate compound as the complex has a high score, maintains its structural composition, and has a larger variation value than the control, thus inhibiting the drug resistance ability of Mycobacterium tuberculosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hung, Tzu-Chieh& Chen, Kuen-Bao& Lee, Wen-Yuan& Chen, Calvin Yu-Chian. 2014. The Inhibition of Folylpolyglutamate Synthetase (folC) in the Prevention of Drug Resistance in Mycobacterium tuberculosis by Traditional Chinese Medicine. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-486928
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hung, Tzu-Chieh…[et al.]. The Inhibition of Folylpolyglutamate Synthetase (folC) in the Prevention of Drug Resistance in Mycobacterium tuberculosis by Traditional Chinese Medicine. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-486928
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hung, Tzu-Chieh& Chen, Kuen-Bao& Lee, Wen-Yuan& Chen, Calvin Yu-Chian. The Inhibition of Folylpolyglutamate Synthetase (folC) in the Prevention of Drug Resistance in Mycobacterium tuberculosis by Traditional Chinese Medicine. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-486928
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-486928
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر