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The Inhibition of Folylpolyglutamate Synthetase (folC) in the Prevention of Drug Resistance in Mycobacterium tuberculosis by Traditional Chinese Medicine
Joint Authors
Lee, Wen-Yuan
Chen, Kuen-Bao
Chen, Calvin Yu-Chian
Hung, Tzu-Chieh
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-19
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Tuberculosis (TB) is an infectious disease caused by many strains of mycobacteria, but commonly Mycobacterium tuberculosis.
As a possible method of reducing the drug resistance of M.
tuberculosis, this research investigates the inhibition of Folylpolyglutamate synthetase, a protein transcript from the resistance association gene folC.
After molecular docking to screen the traditional Chinese medicine (TCM) database, the candidate TCM compounds, with Folylpolyglutamate synthetase, were selected by molecular dynamics.
The 10,000 ps simulation in association with RMSD analysis and total energy and structural variation defined the protein-ligand interaction.
The selected TCM compounds Saussureamine C, methyl 3-O-feruloylquinate, and Labiatic acid have been found to inhibit the activity of bacteria and viruses and to regulate immunity.
We also suggest the possible pathway in protein for each ligand.
Compared with the control, similar interactions and structural variations indicate that these compounds might have an effect on Folylpolyglutamate synthetase.
Finally, we suggest Saussureamine C is the best candidate compound as the complex has a high score, maintains its structural composition, and has a larger variation value than the control, thus inhibiting the drug resistance ability of Mycobacterium tuberculosis.
American Psychological Association (APA)
Hung, Tzu-Chieh& Chen, Kuen-Bao& Lee, Wen-Yuan& Chen, Calvin Yu-Chian. 2014. The Inhibition of Folylpolyglutamate Synthetase (folC) in the Prevention of Drug Resistance in Mycobacterium tuberculosis by Traditional Chinese Medicine. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-486928
Modern Language Association (MLA)
Hung, Tzu-Chieh…[et al.]. The Inhibition of Folylpolyglutamate Synthetase (folC) in the Prevention of Drug Resistance in Mycobacterium tuberculosis by Traditional Chinese Medicine. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-486928
American Medical Association (AMA)
Hung, Tzu-Chieh& Chen, Kuen-Bao& Lee, Wen-Yuan& Chen, Calvin Yu-Chian. The Inhibition of Folylpolyglutamate Synthetase (folC) in the Prevention of Drug Resistance in Mycobacterium tuberculosis by Traditional Chinese Medicine. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-486928
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486928