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Maintenance of Mitochondrial Morphology by Autophagy and Its Role in High Glucose Effects on Chronological Lifespan of Saccharomyces cerevisiae
المؤلفون المشاركون
Aung-Htut, May T.
Rinnerthaler, Mark
Dawes, Ian W.
Lim, Yu-Leng
Breitenbach, Michael
Yang, Hongyuan
Gelling, Cristy L.
Lam, Yuen T.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-11
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
In Saccharomyces cerevisiae, mitochondrial morphology changes when cells are shifted between nonfermentative and fermentative carbon sources.
Here, we show that cells of S.
cerevisiae grown in different glucose concentrations display different mitochondrial morphologies.
The morphology of mitochondria in the cells growing in 0.5% glucose was similar to that of mitochondria in respiring cells.
However, the mitochondria of cells growing in higher glucose concentrations (2% and 4%) became fragmented after growth in these media, due to the production of acetic acid; however, the fragmentation was not due to intracellular acidification.
From a screen of mutants involved in sensing and utilizing nutrients, cells lacking TOR1 had reduced mitochondrial fragmentation, and autophagy was found to be essential for this reduction.
Mitochondrial fragmentation in cells grown in high glucose was reversible by transferring them into conditioned medium from a culture grown on 0.5% glucose.
Similarly, the chronological lifespan of cells grown in high glucose medium was reduced, and this phenotype could be reversed when cells were transferred to low glucose conditioned medium.
These data indicate that chronological lifespan seems correlated with mitochondrial morphology of yeast cells and that both phenotypes can be influenced by factors from conditioned medium of cultures grown in low glucose medium.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Aung-Htut, May T.& Lam, Yuen T.& Lim, Yu-Leng& Rinnerthaler, Mark& Gelling, Cristy L.& Yang, Hongyuan…[et al.]. 2013. Maintenance of Mitochondrial Morphology by Autophagy and Its Role in High Glucose Effects on Chronological Lifespan of Saccharomyces cerevisiae. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-487039
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Aung-Htut, May T.…[et al.]. Maintenance of Mitochondrial Morphology by Autophagy and Its Role in High Glucose Effects on Chronological Lifespan of Saccharomyces cerevisiae. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-487039
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Aung-Htut, May T.& Lam, Yuen T.& Lim, Yu-Leng& Rinnerthaler, Mark& Gelling, Cristy L.& Yang, Hongyuan…[et al.]. Maintenance of Mitochondrial Morphology by Autophagy and Its Role in High Glucose Effects on Chronological Lifespan of Saccharomyces cerevisiae. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-487039
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-487039
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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