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Maintenance of Mitochondrial Morphology by Autophagy and Its Role in High Glucose Effects on Chronological Lifespan of Saccharomyces cerevisiae
Joint Authors
Aung-Htut, May T.
Rinnerthaler, Mark
Dawes, Ian W.
Lim, Yu-Leng
Breitenbach, Michael
Yang, Hongyuan
Gelling, Cristy L.
Lam, Yuen T.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-11
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
In Saccharomyces cerevisiae, mitochondrial morphology changes when cells are shifted between nonfermentative and fermentative carbon sources.
Here, we show that cells of S.
cerevisiae grown in different glucose concentrations display different mitochondrial morphologies.
The morphology of mitochondria in the cells growing in 0.5% glucose was similar to that of mitochondria in respiring cells.
However, the mitochondria of cells growing in higher glucose concentrations (2% and 4%) became fragmented after growth in these media, due to the production of acetic acid; however, the fragmentation was not due to intracellular acidification.
From a screen of mutants involved in sensing and utilizing nutrients, cells lacking TOR1 had reduced mitochondrial fragmentation, and autophagy was found to be essential for this reduction.
Mitochondrial fragmentation in cells grown in high glucose was reversible by transferring them into conditioned medium from a culture grown on 0.5% glucose.
Similarly, the chronological lifespan of cells grown in high glucose medium was reduced, and this phenotype could be reversed when cells were transferred to low glucose conditioned medium.
These data indicate that chronological lifespan seems correlated with mitochondrial morphology of yeast cells and that both phenotypes can be influenced by factors from conditioned medium of cultures grown in low glucose medium.
American Psychological Association (APA)
Aung-Htut, May T.& Lam, Yuen T.& Lim, Yu-Leng& Rinnerthaler, Mark& Gelling, Cristy L.& Yang, Hongyuan…[et al.]. 2013. Maintenance of Mitochondrial Morphology by Autophagy and Its Role in High Glucose Effects on Chronological Lifespan of Saccharomyces cerevisiae. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-487039
Modern Language Association (MLA)
Aung-Htut, May T.…[et al.]. Maintenance of Mitochondrial Morphology by Autophagy and Its Role in High Glucose Effects on Chronological Lifespan of Saccharomyces cerevisiae. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-487039
American Medical Association (AMA)
Aung-Htut, May T.& Lam, Yuen T.& Lim, Yu-Leng& Rinnerthaler, Mark& Gelling, Cristy L.& Yang, Hongyuan…[et al.]. Maintenance of Mitochondrial Morphology by Autophagy and Its Role in High Glucose Effects on Chronological Lifespan of Saccharomyces cerevisiae. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-487039
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487039