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Apoptotic and Inhibitory Effects on Cell Proliferation of Hepatocellular Carcinoma HepG2 Cells by Methanol Leaf Extract of Costus speciosus
المؤلفون المشاركون
Hettihewa, Menik
Nair, Sandhya V. G.
Rupasinghe, H. P. Vasantha
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-10
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Costus speciosus is a medicinal plant commonly known as wild ginger distributed in South and Southeast Asian countries.
Leaves of this plant are used for ayurvedic treatment regimes in malignancies and mental illness.
Rhizome extract from the plant is used to treat malignancies, pneumonia, urinary disorders, jaundice, rheumatism, and diabetes.
The goal of this study was to investigate the effects of methanol extract of leaves of C.
speciosus on the growth of human hepatocellular carcinoma (HepG2) cells and understand possible mechanisms of its action.
Viability of HepG2 cells were measured by MTS assay after 24 h and 48 h treatment with extracts of 1, 10, 50, 100, and 200 μg/mL concentrations.
Cell cycle analysis and apoptosis were evaluated by flow cytometry and caspase-3 induction.
HepG2 cells treated with 100 μg/mL methanol leaf extract for 24 h displayed a significant reduction in cell viability (P≤0.05).
The methanol extract perturbed cell cycle progression, modulated cell cycle and regulated, signal molecules were involved in induction of apoptosis in HepG2 cells.
Our findings indicate that phytochemicals of leaves of C.
speciosus shows potential for natural therapeutic product development for hepatocellular carcinoma.
This is the first report to demonstrate in vitro anticancer activity of leaf extract of C.
speciosus in relation to liver cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nair, Sandhya V. G.& Hettihewa, Menik& Rupasinghe, H. P. Vasantha. 2014. Apoptotic and Inhibitory Effects on Cell Proliferation of Hepatocellular Carcinoma HepG2 Cells by Methanol Leaf Extract of Costus speciosus. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-487101
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nair, Sandhya V. G.…[et al.]. Apoptotic and Inhibitory Effects on Cell Proliferation of Hepatocellular Carcinoma HepG2 Cells by Methanol Leaf Extract of Costus speciosus. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-487101
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nair, Sandhya V. G.& Hettihewa, Menik& Rupasinghe, H. P. Vasantha. Apoptotic and Inhibitory Effects on Cell Proliferation of Hepatocellular Carcinoma HepG2 Cells by Methanol Leaf Extract of Costus speciosus. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-487101
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-487101
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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