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Association between P2X7 Receptor Polymorphisms and Bone Status in Mice
المؤلفون المشاركون
Syberg, Susanne
Jensen, Jens-Erik Beck
Schwarz, Peter
Petersen, Solveig
Teilmann, Jenni
Steinberg, Thomas H.
Jorgensen, Niklas Rye
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-08-05
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Macrophages from mouse strains with the naturally occurring mutation P451L in the purinergic receptor P2X7 have impaired responses to agonists (1).
Because P2X7 receptors are expressed in bone cells and are implicated in bone physiology, we asked whether strains with the P451L mutation have a different bone phenotype.
By sequencing the most common strains of inbred mice, we found that only a few strains (BALB, NOD, NZW, and 129) were harboring the wild allelic version of the mutation (P451) in the gene for the purinergic receptor P2X7.
The strains were compared by means of dual energy X-ray absorptiometry (DXA), bone markers, and three-point bending.
Cultured osteoclasts were used in the ATP-induced pore formation assay.
We found that strains with the P451 allele (BALB/cJ and 129X1/SvJ) had stronger femurs and higher levels of the bone resorption marker C-telopeptide collagen (CTX) compared to C57Bl/6 (B6) and DBA/2J mice.
In strains with the 451L allele, pore-formation activity in osteoclasts in vitro was lower after application of ATP.
In conclusion, two strains with the 451L allele of the naturally occurring mutation P451L, have weaker bones and lower levels of CTX, suggesting lower resorption levels in these animals, which could be related to the decreased ATP-induced pore formation observed in vitro.
The importance of these findings for the interpretation of the earlier reported effects of P2X7 in mice is discussed, along with strategies in developing a murine model for testing the therapeutic effects of P2X7 agonists and antagonists upon postmenopausal osteoporosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Syberg, Susanne& Schwarz, Peter& Petersen, Solveig& Steinberg, Thomas H.& Jensen, Jens-Erik Beck& Teilmann, Jenni…[et al.]. 2012. Association between P2X7 Receptor Polymorphisms and Bone Status in Mice. Journal of Osteoporosis،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-487184
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Syberg, Susanne…[et al.]. Association between P2X7 Receptor Polymorphisms and Bone Status in Mice. Journal of Osteoporosis No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-487184
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Syberg, Susanne& Schwarz, Peter& Petersen, Solveig& Steinberg, Thomas H.& Jensen, Jens-Erik Beck& Teilmann, Jenni…[et al.]. Association between P2X7 Receptor Polymorphisms and Bone Status in Mice. Journal of Osteoporosis. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-487184
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-487184
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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