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Sensorimotor Cortex Reorganization in Alzheimer's Disease and Metal Dysfunction : A MEG Study
المؤلفون المشاركون
Moffa, F.
Tecchio, Franca
Rossini, Paolo Maria
Cassetta, E.
Tomasevic, L.
Squitti, Rosanna
Zappasodi, Filippo
Salustri, Carlo
Ercolani, M.
المصدر
International Journal of Alzheimer's Disease
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-12
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
To verify whether systemic biometals dysfunctions affect neurotransmission in living Alzheimer’s disease (AD) patients.
Methods.
We performed a case-control study using magnetoencephalography to detect sensorimotor fields of AD patients, at rest and during median nerve stimulation.
We analyzed position and amount of neurons synchronously activated by the stimulation in both hemispheres to investigate the capability of the primary somatosensory cortex to reorganize its circuitry disrupted by the disease.
We also assessed systemic levels of copper, ceruloplasmin, non-Cp copper (i.e., copper not bound to ceruloplasmin), peroxides, transferrin, and total antioxidant capacity.
Results.
Patients’ sensorimotor generators appeared spatially shifted, despite no change of latency and strength, while spontaneous activity sources appeared unchanged.
Neuronal reorganization was greater in moderately ill patients, while delta activity increased in severe patients.
Non-Cp copper was the only biological variable appearing to be associated with patient sensorimotor transmission.
Conclusions.
Our data strengthen the notion that non-Cp copper, not copper in general, affects neuronal activity in AD.
Significance.
High plasticity in the disease early stages in regions controlling more commonly used body parts strengthens the notion that physical and cognitive activities are protective factors against progression of dementia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Salustri, Carlo& Tecchio, Franca& Zappasodi, Filippo& Tomasevic, L.& Ercolani, M.& Moffa, F.…[et al.]. 2013. Sensorimotor Cortex Reorganization in Alzheimer's Disease and Metal Dysfunction : A MEG Study. International Journal of Alzheimer's Disease،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-487233
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Salustri, Carlo…[et al.]. Sensorimotor Cortex Reorganization in Alzheimer's Disease and Metal Dysfunction : A MEG Study. International Journal of Alzheimer's Disease No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-487233
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Salustri, Carlo& Tecchio, Franca& Zappasodi, Filippo& Tomasevic, L.& Ercolani, M.& Moffa, F.…[et al.]. Sensorimotor Cortex Reorganization in Alzheimer's Disease and Metal Dysfunction : A MEG Study. International Journal of Alzheimer's Disease. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-487233
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-487233
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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