Sensorimotor Cortex Reorganization in Alzheimer's Disease and Metal Dysfunction : A MEG Study
Joint Authors
Moffa, F.
Tecchio, Franca
Rossini, Paolo Maria
Cassetta, E.
Tomasevic, L.
Squitti, Rosanna
Zappasodi, Filippo
Salustri, Carlo
Ercolani, M.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To verify whether systemic biometals dysfunctions affect neurotransmission in living Alzheimer’s disease (AD) patients.
Methods.
We performed a case-control study using magnetoencephalography to detect sensorimotor fields of AD patients, at rest and during median nerve stimulation.
We analyzed position and amount of neurons synchronously activated by the stimulation in both hemispheres to investigate the capability of the primary somatosensory cortex to reorganize its circuitry disrupted by the disease.
We also assessed systemic levels of copper, ceruloplasmin, non-Cp copper (i.e., copper not bound to ceruloplasmin), peroxides, transferrin, and total antioxidant capacity.
Results.
Patients’ sensorimotor generators appeared spatially shifted, despite no change of latency and strength, while spontaneous activity sources appeared unchanged.
Neuronal reorganization was greater in moderately ill patients, while delta activity increased in severe patients.
Non-Cp copper was the only biological variable appearing to be associated with patient sensorimotor transmission.
Conclusions.
Our data strengthen the notion that non-Cp copper, not copper in general, affects neuronal activity in AD.
Significance.
High plasticity in the disease early stages in regions controlling more commonly used body parts strengthens the notion that physical and cognitive activities are protective factors against progression of dementia.
American Psychological Association (APA)
Salustri, Carlo& Tecchio, Franca& Zappasodi, Filippo& Tomasevic, L.& Ercolani, M.& Moffa, F.…[et al.]. 2013. Sensorimotor Cortex Reorganization in Alzheimer's Disease and Metal Dysfunction : A MEG Study. International Journal of Alzheimer's Disease،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-487233
Modern Language Association (MLA)
Salustri, Carlo…[et al.]. Sensorimotor Cortex Reorganization in Alzheimer's Disease and Metal Dysfunction : A MEG Study. International Journal of Alzheimer's Disease No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-487233
American Medical Association (AMA)
Salustri, Carlo& Tecchio, Franca& Zappasodi, Filippo& Tomasevic, L.& Ercolani, M.& Moffa, F.…[et al.]. Sensorimotor Cortex Reorganization in Alzheimer's Disease and Metal Dysfunction : A MEG Study. International Journal of Alzheimer's Disease. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-487233
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487233