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Increased B-Type Natriuretic Peptide Concentration Is Associated with Reduced Coronary Vasoreactivity in Patients with Dilated Cardiomyopathy but Not in Healthy Young Subjects
المؤلفون المشاركون
Koistinen, Juhani
Knuuti, Juhani
Sundell, Jan
Engblom, Erik
Bax, Jeroen J.
Ylitalo, Antti
Airaksinen, K. E. Juhani
Kalliokoski, Riikka
Laine, Hanna
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-04-11
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background/Aims.
Natriuretic peptides are associated with the cardiovascular disease risk under a range of different circumstances.
However, less is known about whether this association is found also in young healthy subjects.
Methods.
9 patients with dilated cardiomyopathy and 26 healthy young subjects were studied.
The myocardial blood flow measurements were performed basally and during adenosine infusion using PET.
Results.
S-proBNP concentrations were significantly higher (2153±1964 versus 28±17 ng/L, P=.000002) and adenosine-stimulated flow lower (1.6±0.8 versus 3.6±1.1 mL⋅g−1⋅min−1, P=.00001) in patients with dilated cardiomyopathy when compared to healthy subjects.
S-proBNP concentration was inversely associated with adenosine stimulated flow in patients with dilated cardiomyopathy (r=−0.75, P=.019) but not in healthy subjects (r=−0.06, P=.84).
Conclusions.
Natriuretic peptides are inversely associated with coronary vasoreactivity in patients with dilated cardiomyopathy but not in healthy young subjects.
Since reduced coronary vasoreactivity seems to be one of the earliest abnormalities in the development of coronary artery disease, this might indicate that natriuretic peptides are not predictor of cardiovascular disease risk in healthy young subjects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sundell, Jan& Engblom, Erik& Koistinen, Juhani& Ylitalo, Antti& Laine, Hanna& Kalliokoski, Riikka…[et al.]. 2011. Increased B-Type Natriuretic Peptide Concentration Is Associated with Reduced Coronary Vasoreactivity in Patients with Dilated Cardiomyopathy but Not in Healthy Young Subjects. ISRN Cardiology،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-487273
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sundell, Jan…[et al.]. Increased B-Type Natriuretic Peptide Concentration Is Associated with Reduced Coronary Vasoreactivity in Patients with Dilated Cardiomyopathy but Not in Healthy Young Subjects. ISRN Cardiology No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-487273
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sundell, Jan& Engblom, Erik& Koistinen, Juhani& Ylitalo, Antti& Laine, Hanna& Kalliokoski, Riikka…[et al.]. Increased B-Type Natriuretic Peptide Concentration Is Associated with Reduced Coronary Vasoreactivity in Patients with Dilated Cardiomyopathy but Not in Healthy Young Subjects. ISRN Cardiology. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-487273
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-487273
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