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Increased B-Type Natriuretic Peptide Concentration Is Associated with Reduced Coronary Vasoreactivity in Patients with Dilated Cardiomyopathy but Not in Healthy Young Subjects
Joint Authors
Koistinen, Juhani
Knuuti, Juhani
Sundell, Jan
Engblom, Erik
Bax, Jeroen J.
Ylitalo, Antti
Airaksinen, K. E. Juhani
Kalliokoski, Riikka
Laine, Hanna
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-11
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background/Aims.
Natriuretic peptides are associated with the cardiovascular disease risk under a range of different circumstances.
However, less is known about whether this association is found also in young healthy subjects.
Methods.
9 patients with dilated cardiomyopathy and 26 healthy young subjects were studied.
The myocardial blood flow measurements were performed basally and during adenosine infusion using PET.
Results.
S-proBNP concentrations were significantly higher (2153±1964 versus 28±17 ng/L, P=.000002) and adenosine-stimulated flow lower (1.6±0.8 versus 3.6±1.1 mL⋅g−1⋅min−1, P=.00001) in patients with dilated cardiomyopathy when compared to healthy subjects.
S-proBNP concentration was inversely associated with adenosine stimulated flow in patients with dilated cardiomyopathy (r=−0.75, P=.019) but not in healthy subjects (r=−0.06, P=.84).
Conclusions.
Natriuretic peptides are inversely associated with coronary vasoreactivity in patients with dilated cardiomyopathy but not in healthy young subjects.
Since reduced coronary vasoreactivity seems to be one of the earliest abnormalities in the development of coronary artery disease, this might indicate that natriuretic peptides are not predictor of cardiovascular disease risk in healthy young subjects.
American Psychological Association (APA)
Sundell, Jan& Engblom, Erik& Koistinen, Juhani& Ylitalo, Antti& Laine, Hanna& Kalliokoski, Riikka…[et al.]. 2011. Increased B-Type Natriuretic Peptide Concentration Is Associated with Reduced Coronary Vasoreactivity in Patients with Dilated Cardiomyopathy but Not in Healthy Young Subjects. ISRN Cardiology،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-487273
Modern Language Association (MLA)
Sundell, Jan…[et al.]. Increased B-Type Natriuretic Peptide Concentration Is Associated with Reduced Coronary Vasoreactivity in Patients with Dilated Cardiomyopathy but Not in Healthy Young Subjects. ISRN Cardiology No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-487273
American Medical Association (AMA)
Sundell, Jan& Engblom, Erik& Koistinen, Juhani& Ylitalo, Antti& Laine, Hanna& Kalliokoski, Riikka…[et al.]. Increased B-Type Natriuretic Peptide Concentration Is Associated with Reduced Coronary Vasoreactivity in Patients with Dilated Cardiomyopathy but Not in Healthy Young Subjects. ISRN Cardiology. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-487273
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487273