miR-21 Is a Promising Novel Biomarker for Lymph Node Metastasis in Patients with Gastric Cancer
المؤلفون المشاركون
Sun, Jue
Xu, Yuejuan
Xu, Jianhua
Li, Qi
Zhang, Qiang
Guo, Yuewu
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-27
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
Gastric cancer (GC) is an important malignant disease around the world.
Abnormalities of microRNAs (miRNAs) have been implicated in carcinogenesis of various cancers.
In the present study, we examined miR-21 expression in human gastric cancer with lymph node metastasis and attempted to uncover its relationship with clinicopathologic data, especially with lymph node metastasis.
Materials and Methods.
The expression levels of miR-21 in the tumor specimens of GC patients were quantified by RT-PCR.
The correlation between miR-21 level and multiple clinicopathological factors was then examined by Mann-Whitney test, Kaplan-Meier survival analysis, and operating characteristic (ROC) analysis.
Results.
The expression level of miR-21 was higher in GC patients with lymph node metastasis than in those without lymph node metastasis (P<0.05).
Expression level of miR-21 was significantly correlated with histologic type, T stage, lymph node metastasis and pTNM stage.
The overall survival rates in GC patients with low upregulated miR-21 expression were significantly higher than those with high upregulated miR-21 (P<0.05).
Conclusion.
A close association is implicated between the elevated miR-21and lymph node metastasis, which could potentially be exploited as a practical biomarker for lymph node metastasis in patients with GC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Yuejuan& Sun, Jue& Xu, Jianhua& Li, Qi& Guo, Yuewu& Zhang, Qiang. 2012. miR-21 Is a Promising Novel Biomarker for Lymph Node Metastasis in Patients with Gastric Cancer. Gastroenterology Research and Practice،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-487389
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Yuejuan…[et al.]. miR-21 Is a Promising Novel Biomarker for Lymph Node Metastasis in Patients with Gastric Cancer. Gastroenterology Research and Practice No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-487389
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Yuejuan& Sun, Jue& Xu, Jianhua& Li, Qi& Guo, Yuewu& Zhang, Qiang. miR-21 Is a Promising Novel Biomarker for Lymph Node Metastasis in Patients with Gastric Cancer. Gastroenterology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-487389
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-487389
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر